Table of Contents
ISRN Toxicology
Volume 2013 (2013), Article ID 792452, 7 pages
http://dx.doi.org/10.1155/2013/792452
Research Article

Activation of the NFκB Pathway Enhances AhR Expression in Intestinal Caco-2 Cells

1IMBE-UMR CNRS 7263, IRD 237 Aix-Marseille Université Campus Timone, Faculté de Pharmacie, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France
2UMR INSERM 1062, INRA 1260, Nutrition, Obésité et Risque Thrombotique (NORT), Aix-Marseille Université Campus Timone, Faculté de Pharmacie, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France
3Laboratoire de Génie Génétique, Aix-Marseille Université Campus Timone, Faculté de Pharmacie, 27 boulevard Jean Moulin, 13385 Marseille Cedex 05, France

Received 4 July 2013; Accepted 21 August 2013

Academic Editors: P. Pocar and J. C. Rowlands

Copyright © 2013 S. Champion et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. W. Nebert, T. P. Dalton, A. B. Okey, and F. J. Gonzalez, “Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer,” The Journal of Biological Chemistry, vol. 279, no. 23, pp. 23847–23850, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. B. J. McMillan and C. A. Bradfield, “The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems,” Molecular Pharmacology, vol. 72, no. 3, pp. 487–498, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Barouki, X. Coumoul, and P. M. Fernandez-Salguero, “The aryl hydrocarbon receptor, more than a xenobiotic-interacting protein,” FEBS Letters, vol. 581, no. 19, pp. 3608–3615, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Belpomme, P. Irigaray, L. Hardell et al., “The multitude and diversity of environmental carcinogens,” Environmental Research, vol. 105, no. 3, pp. 414–429, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. O. Humblet, L. Birnbaum, E. Rimm, M. A. Mittleman, and R. Hauser, “Dioxins and cardiovascular disease mortality,” Environmental Health Perspectives, vol. 116, no. 11, pp. 1443–1448, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. D. O. Carpenter, “Environmental contaminants as risk factors for developing diabetes,” Reviews on Environmental Health, vol. 23, no. 1, pp. 59–74, 2008. View at Google Scholar · View at Scopus
  7. K. Pande, S. M. Moran, and C. A. Bradfield, “Aspects of dioxin toxicity are mediated by interleukin 1-like cytokines,” Molecular Pharmacology, vol. 67, no. 5, pp. 1393–1398, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. P. H. Villard, S. Caverni, A. Baanannou et al., “PPARα transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects,” Biochemical and Biophysical Research Communications, vol. 364, no. 4, pp. 896–901, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Khalil, P.-H. Villard, M. A. Dao et al., “Polycyclic aromatic hydrocarbons potentiate high-fat diet effects on intestinal inflammation,” Toxicology Letters, vol. 196, no. 3, pp. 161–167, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Cheon, Y.-S. Woo, Y. L. Ji et al., “Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-α production in differentiated THP-1 human macrophages,” Experimental and Molecular Medicine, vol. 39, no. 4, pp. 524–534, 2007. View at Google Scholar · View at Scopus
  11. B. D. Hollingshead, T. V. Beischlag, B. C. DiNatale, P. Ramadoss, and G. H. Perdew, “Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells,” Cancer Research, vol. 68, no. 10, pp. 3609–3617, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Podechard, V. Lecureur, E. Le Ferrec et al., “Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation,” Toxicology Letters, vol. 177, no. 2, pp. 130–137, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. V. R. C. De Souza, W. K. Cabrera, A. Galvan et al., “Aryl hydrocarbon receptor polymorphism modulates DMBA-induced inflammation and carcinogenesis in phenotypically selected mice,” International Journal of Cancer, vol. 124, no. 6, pp. 1478–1482, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. E. M. Drummond, N. Harbourne, E. Marete et al., “Inhibition of proinflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark,” Phytotherapy Research, vol. 27, no. 4, pp. 588–594, 2013. View at Google Scholar
  15. A. Parlesak, D. Haller, S. Brinz, A. Baeuerlein, and C. Bode, “Modulation of cytokine release by differentiated CACO-2 cells in a compartmentalized coculture model with mononuclear leucocytes and nonpathogenic bacteria,” Scandinavian Journal of Immunology, vol. 60, no. 5, pp. 477–485, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. C. Huang, Y. Huang, J. Li et al., “Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor κB by black raspberry extracts,” Cancer Research, vol. 62, no. 23, pp. 6857–6863, 2002. View at Google Scholar · View at Scopus
  17. C. Carlens, M.-P. Hergens, J. Grunewald et al., “Smoking, use of moist snuff, and risk of chronic inflammatory diseases,” American Journal of Respiratory and Critical Care Medicine, vol. 181, no. 11, pp. 1217–1222, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. N. A. Molodecky and G. G. Kaplan, “Environmental risk factors for inflammatory bowel disease,” Gastroenterology and Hepatology, vol. 6, no. 5, pp. 339–346, 2010. View at Google Scholar · View at Scopus
  19. R. Arsenescu, V. Arsenescu, J. Zhong et al., “Role of the xenobiotic receptor in inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 17, no. 5, pp. 1149–1162, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Shimada and Y. Fujii-Kuriyama, “Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1,” Cancer Science, vol. 95, no. 1, pp. 1–6, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Tian, S. Ke, M. S. Denison, A. B. Rabson, and M. A. Gallo, “Ah receptor and NF-κB interactions, a potential mechanism for dioxin toxicity,” The Journal of Biological Chemistry, vol. 274, no. 1, pp. 510–515, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. B. A. Jensen, R. J. Leeman, J. J. Schlezinger, and D. H. Sherr, “Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study,” Environmental Health, vol. 2, article 1, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. C. F. A. Vogel, E. Sciullo, W. Li, P. Wong, G. Lazennec, and F. Matsumura, “RelB, a new partner of aryl hydrocarbon receptor-mediated transcription,” Molecular Endocrinology, vol. 21, no. 12, pp. 2941–2955, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. C. F. A. Vogel, N. Nishimura, E. Sciullo, P. Wong, W. Li, and F. Matsumura, “Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice,” Archives of Biochemistry and Biophysics, vol. 461, no. 2, pp. 169–175, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. C. F. A. Vogel and F. Matsumura, “A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-κB family,” Biochemical Pharmacology, vol. 77, no. 4, pp. 734–745, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Revel, H. Raanani, E. Younglai et al., “Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene,” Journal of Applied Toxicology, vol. 23, no. 4, pp. 255–261, 2003. View at Publisher · View at Google Scholar · View at Scopus