Table of Contents
ISRN Pharmacology
Volume 2013 (2013), Article ID 792456, 5 pages
http://dx.doi.org/10.1155/2013/792456
Research Article

Comparative Cytochrome P450 In Vitro Inhibition by Atypical Antipsychotic Drugs

Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n, 06071 Badajoz, Spain

Received 19 December 2012; Accepted 8 January 2013

Academic Editors: K. Cimanga, G. Froldi, D. K. Miller, R. Villalobos-Molina, and T. B. Vree

Copyright © 2013 Guillermo Gervasini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Lowe, T. F. Seeger, and F. J. Vinick, “Atypical antipsychotics—recent findings and new perspectives,” Medicinal Research Reviews, vol. 8, no. 4, pp. 475–497, 1988. View at Google Scholar · View at Scopus
  2. L. P. Pan, P. Wijnant, C. De Vriendt, M. T. Rosseel, and F. M. Belpaire, “Characterization of the cytochrome P450 isoenzymes involved in the in vitroN-dealkylation of haloperidol,” British Journal of Clinical Pharmacology, vol. 44, no. 6, pp. 557–564, 1997. View at Google Scholar · View at Scopus
  3. J. A. Carrillo, A. G. Herráiz, S. I. Ramos, G. Gervasini, S. Vizcaíno, and J. Benítez, “Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine,” Journal of Clinical Psychopharmacology, vol. 23, no. 2, pp. 119–127, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Bertilsson, J. A. Carrillo, M. L. Dahl et al., “Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test,” British Journal of Clinical Pharmacology, vol. 38, no. 5, pp. 471–473, 1994. View at Google Scholar · View at Scopus
  5. J. A. Carrillo, A. G. Herraiz, S. I. Ramos, and J. Benítez, “Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients,” Journal of Clinical Psychopharmacology, vol. 18, no. 4, pp. 311–316, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Benítez, M. L. Dahl, E. Spina, and J. A. Carrillo, “Genetic an environmental factors causing variability in psychotropic drug response,” in Interindividual Variability in Human Drug Metabolism, G. M. Pacifici and O. Pelkonen, Eds., pp. 85–128, Taylor & Francis, London, UK, 2001. View at Google Scholar
  7. E. L. Michalets, “Update: clinically significant cytochrome P-450 drug interactions,” Pharmacotherapy, vol. 18, no. 1, pp. 84–112, 1998. View at Google Scholar · View at Scopus
  8. J. O. Miners and D. J. Birkett, “Cytochrome P4502C9: an enzyme of major importance in human drug metabolism,” British Journal of Clinical Pharmacology, vol. 45, no. 6, pp. 525–538, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Wójcikowski and W. A. Daniel, “Influence of antidepressant drugs on chlorpromazine metabolism in human liver—an in vitro study,” Pharmacological Reports, vol. 62, no. 6, pp. 1062–1069, 2010. View at Google Scholar · View at Scopus
  10. J. Wójcikowski and W. A. Daniel, “Thioridazine-fluoxetine interaction at the level of the distribution process in vivo,” Pharmacological Reports, vol. 54, no. 6, pp. 647–654, 2002. View at Google Scholar · View at Scopus
  11. J. A. Carrillo, S. I. Ramos, A. G. Herraiz et al., “Pharmacokinetic interaction of fluvoxamine and thioridazine in schizophrenic patients,” Journal of Clinical Psychopharmacology, vol. 19, no. 6, pp. 494–499, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. O. V. Olesen and K. Linnet, “Fluvoxamine-clozapine drug interaction: inhibition in vitro of five cytochrome P450 isoforms involved in clozapine metabolism,” Journal of Clinical Psychopharmacology, vol. 20, no. 1, pp. 35–42, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Spina, A. Avenoso, M. G. Scordo et al., “Inhibition of risperidone metabolism by fluoxetine in patients with schizophrenia: a clinically relevant pharmacokinetic drug interaction,” Journal of Clinical Psychopharmacology, vol. 22, no. 4, pp. 419–423, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Nakagami, N. Yasui-Furukori, M. Saito et al., “Thioridazine inhibits risperidone metabolism: a clinically relevant drug interaction,” Journal of Clinical Psychopharmacology, vol. 25, no. 1, pp. 89–91, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Bolós, S. Gubert, L. Anglada et al., “7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics,” Journal of Medicinal Chemistry, vol. 39, no. 15, pp. 2962–2970, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Bolós, L. Anglada, S. Gubert et al., “7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]propoxy]-3-(hydroxymethyl)chromen-4-one (abaperidone, FI-8602),” Journal of Medicinal Chemistry, vol. 41, no. 27, pp. 5402–5409, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Z. Cer, U. Mudunuri, R. Stephens, and F. J. Lebeda, “IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding,” Nucleic Acids Research, vol. 37, no. 2, pp. W441–W445, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Kirchherr and W. N. Kühn-Velten, “Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach,” Journal of Chromatography B, vol. 843, no. 1, pp. 100–113, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. A. R. Boobis, “Prediction of inhibitory drug-drug interactions by studies in vitro,” in Advances in Drug Metabolism in Man, G. Pacifici and G. Fracchia, Eds., pp. 513–539, The European Commission, Luxembourgm, 1995. View at Google Scholar
  20. J. A. Agúndez, L. Gallardo, C. Martínez, G. Gervasini, and J. Benítez, “Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine,” Pharmacogenetics, vol. 8, no. 3, pp. 251–258, 1998. View at Google Scholar · View at Scopus
  21. G. Gervasini, C. Martínez, J. A. G. Agúndez, F. J. García-Gamito, and J. Benítez, “Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline,” Pharmacogenetics, vol. 11, no. 1, pp. 29–37, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Gervasini, C. Martinez, J. Benitez, and J. A. Agúndez, “Effect of neurotransmitters on NADPH-cytochrome P450 reductase in vitro activity,” Drug Metabolism Letters, vol. 1, no. 3, pp. 172–175, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Martínez, J. A. G. Agúndez, G. Gervasini, R. Martín, and J. Benítez, “Tryptamine: a possible endogenous substrate for CYP2D6,” Pharmacogenetics, vol. 7, no. 2, pp. 85–93, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Martínez, G. Gervasini, J. A. G. Agúndez et al., “Modulation of midazolam 1-hydroxylation activity in vitro by neurotransmitters and precursors,” European Journal of Clinical Pharmacology, vol. 56, no. 2, pp. 145–151, 2000. View at Google Scholar · View at Scopus
  25. J. Wójcikowski, J. Boksa, and W. A. Daniel, “Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver—a comparison with other phenothiazines,” Biochemical Pharmacology, vol. 80, no. 8, pp. 1252–1259, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. J. G. Shin, N. Soukhova, and D. A. Flockhart, “Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6,” Drug Metabolism and Disposition, vol. 27, no. 9, pp. 1078–1084, 1999. View at Google Scholar · View at Scopus
  27. C. B. Eap, G. Bondolfi, D. Zullino et al., “Pharmacokinetic drug interaction potential of risperidone with cytochrome P450 isozymes as assessed by the dextromethorphan, the caffeine, and the mephenytoin test,” Therapeutic Drug Monitoring, vol. 23, no. 3, pp. 228–231, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Spina, C. Martines, A. P. Caputi et al., “Debrisoquine oxidation phenotype during neuroleptic monotherapy,” European Journal of Clinical Pharmacology, vol. 41, no. 5, pp. 467–470, 1991. View at Google Scholar · View at Scopus
  29. R. B. Waade, H. Christensen, I. Rudberg, H. Refsum, and M. Hermann, “Influence of comedication on serum concentrations of aripiprazole and dehydroaripiprazole,” Therapeutic Drug Monitoring, vol. 31, no. 2, pp. 233–238, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. E. C. Dinovo, R. O. Bost, I. Sunshine, and L. A. Gottschalk, “Distribution of thioridazine and its metabolites in human tissues and fluids obtained postmortem,” Clinical Chemistry, vol. 24, no. 10, pp. 1828–1830, 1978. View at Google Scholar · View at Scopus
  31. A. Forsman, M. Larsson, H. Lundborg, and P. Renstrom, “On the distribution and elimination of haloperidol in cholecystectomized patients,” European Journal of Drug Metabolism and Pharmacokinetics, vol. 6, no. 4, pp. 249–253, 1981. View at Google Scholar · View at Scopus
  32. J. I. Javaid, “Clinical pharmacokinetics of antipsychotics,” Journal of Clinical Pharmacology, vol. 34, no. 4, pp. 286–295, 1994. View at Google Scholar · View at Scopus
  33. C. L. DeVane and J. S. Markowitz, “Antipsychotics,” in Metabolic Drug Interactions, R. Levy, K. Thummel, W. Trager, P. Hansten, and M. Eichelbaum, Eds., pp. 245–257, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2000. View at Google Scholar
  34. K. Thummel, K. Kunze, and D. Shen, “Metabolically-based drug-drug interactions: principles and mechanisms,” in Metabolic Drug Interactions, R. Levy, K. Thummel, W. Trager, P. Hansten, and M. Eichelbaum, Eds., pp. 3–19, Lippincott Williams & Wilkins,, Philadelphia, Pa, USA, 2000. View at Google Scholar
  35. U. Schmitt, K. Krischbaum, B. Poller et al., “In vitro P-glycoprotein efflux inhibition by atypical antipsychotics is in vivo nicely reflected by pharmacodynamic but less by pharmacokinetic changes,” Pharmacology Biochemistry and Behavior, vol. 102, no. 2, pp. 312–320, 2012. View at Publisher · View at Google Scholar