Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients

Figure 1

Enumeration of antigen-specific CD4⁺IFN-γ ⁺TNF-α ⁺ T cells in HHC and TB patients. Scatter plots show antigen-specific CD4⁺IFN-γ ⁺TNF-α ⁺ T cells in HHC and TB patients. The frequency of antigen-specific ((a) PPD, (b) ESAT-6, and (c) CFP-10) CD4⁺IFN-γ ⁺TNF-α ⁺ T cells was significantly higher in TB patients compared to HHC for all three antigens. The difference between HHC and TB was calculated by Mann-Whitney 𝑈 test. TB: tuberculosis patients; HHCs: healthy household contacts.

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