Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients

Table 1

Enumeration of antigen-specific IFN-γ, IL-2, and TNF-α T cells in HHC and TB patients.

Cytokine	Antigen	HHC; median (range)	TB; median (range)	𝑃 value
CD4 IFN-𝛾	PPD	0.30 (0–4.4)	0.9 (0–5.6)	0.137
	ESAT-6	0.39 (0.09–3.4)	0.8 (0.1–3.8)	0.101
	CFP-10	0.36 (0.1–6.7)	0.67 (0.13–2.4)	0.747
CD8 IFN-𝛾	PPD	0.35 (0.1–2)	0.52 (0–1.4)	0.901
	ESAT-6	0.43 (0.04–1.9)	0.56 (0–1.8)	0.989
	CFP-10	0.24 (0.1–1.1)	0.48 (0.06–2.0)	0.089
CD4 TNF-𝛼	PPD	0.37 (0.1–1.3)	0.57 (0–2.1)	0.036
	ESAT-6	0.39 (0.2–2.4)	0.53 (0–2.1)	0.651
	CFP-10	0.38 (0.1–6.7)	0.48 (0.1–5.9)	0.826
CD8 TNF-𝛼	PPD	0.54 (0.1–2.0)	0.62 (0–4.0)	0.505
	ESAT-6	0.47 (0.16–3.1)	0.62 (0.18–5.1)	0.722
	CFP-10	0.47 (0–2.8)	0.64 (0–3.1)	0.639
CD4 IL-2	PPD	0.47 (0.0–2.1)	0.58 (0–5.9)	0.181
	ESAT-6	0.32 (0–4.1)	0.53 (0.1–1.9)	0.798
	CFP-10	0.22 (0–4.6)	0.74 (0–2.3)	0.639
CD8 IL-2	PPD	0.55 (0.1–2.3)	0.38 (0–4.0)	0.730
	ESAT-6	0.42 (0.1–2.7)	0.49 (0–4.9)	0.791
	CFP-10	0.44 (0–2.2)	0.24 (0–3.2)	0.836