Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients

Table 2

Sensitivity and specificity for CD4⁺IFN-𝛾⁺TNF-𝛼⁺ and CD8⁺IFN-𝛾⁺TNF-𝛼⁺ T cells in discriminating HHC and TB patients.

Phenotype	Antigen	Cut-off value	% Sensitivity (95% CI)	% Specificity (95% CI)
CD4	PPD	0.27	48 (27.8–68.7)	96 (79.7–99.9)
	ESAT-6	0.23	48 (27.8–68.7)	100
	CFP-10	0.31	52 (31.3–72.2)	96 (74.7–99.9)
	ESAT-6 + CFP-10		68 (49.7–86.3)	96 (79.7–99.9)
CD8	PPD	0.27	36 (18.0–57.5)	96 (79.7–99.9)
	ESAT-6	0.24	20 (6.8–40.7)	96 (79.7–99.9)
	CFP-10	0.20	32 (15–53.5)	96 (79.7–99.9)
	ESAT-6 + CFP-10		32 (15–53.5)	96 (79.7–99.9)