Microwave-Assisted Derivatization of Bile Acids for Gas Chromatography/Mass Spectrometry Determination
Fragmentation patterns of the bile acid TMS (oximes) derivatives obtained using gas chromatography and mass spectrometry (GC/MS) and the common ions in the fragmentation patterns of cholic acid (conventional and microwave-assisted derivatization) and ursodesoxycholic acid (MAD) presented as relative intensities.
Selected fragment ions for identification and quantification
Frequent ion in fragmentation
Further abundant fragment ion, m/z
Relative intensity (%) microwave
Relative intensity (%) conventional
[M − 2TMSOH]+ = 516
[M − (2TMSOH + SiCH4)]+ = 428
[M − 3TMSOH]+ = 426
[M − 2TMSOH]+ = 428
[M − (15 + 2TMSOH)]+ = 413
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