Role of HPV-16 in Pathogenesis of Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma and Correlation of p16INK4A Expression in HPV-16 Positive Cases: An Immunohistochemical Study
Table 4
P16INK4A immunohistochemistry in HPV 16 positive cases.
Sr. no.
Histopath. diagnosis
P16 positivity in percentage (per 1 cm2 area)
Area 1
Area 2
Area 3
Area 4
Area 5
Avg. (%)
(1)
OED
54.90
50.0
71.95
60.0
65.0
60.37
(2)
OED
5.2
6.7
7.8
9.3
2.4
6.28
(3)
WDOSCC
56.99
62.21
59.98
63.04
60.88
60.62
(4)
WDOSCC
0.0
0.0
1.3
0.0
2.5
0.76
(5)
WDOSCC
68.36
46.83
80.0
76.92
61.22
66.66
(6)
WDOSCC
63.56
64.21
63.33
58.39
59.57
60.81
(7)
WDOSCC
0.0
0.0
0.0
0.0
0.0
0.0
(8)
MDOSCC
60.77
65.79
64.44
57.05
59.74
61.56
(9)
PDOSCC
14.47
24.35
32.5
51.17
27.43
29.98
Overall mean and SD of all 9 slides are 60.62% and 12.56%, respectively.
