Table of Contents
ISRN Ophthalmology
Volume 2013 (2013), Article ID 814814, 7 pages
http://dx.doi.org/10.1155/2013/814814
Research Article

Lens Injury Has a Protective Effect on Photoreceptors in the RCS Rat

1Department of Ophthalmology, University of Münster Medical School, Domagkstraße 15, 48149 Münster, Germany
2Centre for Ophthalmology, Experimental Vitreoretinal Surgery, Schleichstraße 12/1, 72076 Tübingen, Germany
3Experimental Neurology, Department of Neurology, Heinrich Heine University, Life Science Centre, Merowingerplatz 1a, D-40225 Düsseldorf, Germany
4Experimental Neurology, University Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany

Received 10 June 2013; Accepted 5 August 2013

Academic Editors: M. Nakazawa and Y. F. Shih

Copyright © 2013 Peter Heiduschka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Fischer, M. Pavlidis, and S. Thanos, “Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture,” Investigative Ophthalmology and Visual Science, vol. 41, no. 12, pp. 3943–3954, 2000. View at Google Scholar · View at Scopus
  2. S. Leon, Y. Yin, J. Nguyen, N. Irwin, and L. I. Benowitz, “Lens injury stimulates axon regeneration in the mature rat optic nerve,” The Journal of Neuroscience, vol. 20, no. 12, pp. 4615–4626, 2000. View at Google Scholar · View at Scopus
  3. D. Fischer, P. Heiduschka, and S. Thanos, “Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats,” Experimental Neurology, vol. 172, no. 2, pp. 257–272, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Lorber, M. Berry, and A. Logan, “Lens injury stimulates adult mouse retinal ganglion cell axon regeneration via both macrophage- and lens-derived factors,” European Journal of Neuroscience, vol. 21, no. 7, pp. 2029–2034, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Fischer, T. G. Hauk, A. Müller, and S. Thanos, “Crystallins of the β/γ-superfamily mimic the effects of lens injury and promote axon regeneration,” Molecular and Cellular Neuroscience, vol. 37, no. 3, pp. 471–479, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Müller, T. G. Hauk, and D. Fischer, “Astrocyte-derived CNTF switches mature RGCs to a regenerative state following inflammatory stimulation,” Brain, vol. 130, no. 12, pp. 3308–3320, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Joly, C. Lange, M. Thiersch, M. Samardzija, and C. Grimm, “Leukemia inhibitory factor extends the lifespan of injured photoreceptors in vivo,” The Journal of Neuroscience, vol. 28, no. 51, pp. 13765–13774, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Bürgi, M. Samardzija, and C. Grimm, “Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration,” Molecular Vision, vol. 15, pp. 1631–1637, 2009. View at Google Scholar · View at Scopus
  9. M. Leibinger, A. Müller, A. Andreadaki, T. G. Hauk, M. Kirsch, and D. Fischer, “Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor,” The Journal of Neuroscience, vol. 29, no. 45, pp. 14334–14341, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Müller, T. G. Hauk, M. Leibinger, R. Marienfeld, and D. Fischer, “Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF,” Molecular and Cellular Neuroscience, vol. 41, no. 2, pp. 233–246, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Fischer, “What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 3, p. E8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Leibinger, A. Müller, P. Gobrecht, H. Diekmann, A. Andreadaki, and D. Fischer, “Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation,” Cell Death and Disease, vol. 4, article e609, 2013. View at Google Scholar
  13. J. E. Dowling and R. L. Sidman, “Inherited retinal dystrophy in the rat,” The Journal of Cell Biology, vol. 14, pp. 73–109, 1962. View at Google Scholar
  14. P. M. D'Cruz, D. Yasumura, J. Weir et al., “Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat,” Human Molecular Genetics, vol. 9, no. 4, pp. 645–651, 2000. View at Google Scholar · View at Scopus
  15. A. Gal, Y. Li, D. A. Thompson et al., “Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa,” Nature Genetics, vol. 26, no. 3, pp. 270–271, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. J. Brea-Fernández, E. Pomares, M. J. Brión et al., “Novel splice donor site mutation in MERTK gene associated with retinitis pigmentosa,” British Journal of Ophthalmology, vol. 92, no. 10, pp. 1419–1423, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Lorber, M. Berry, A. Logan, and D. Tonge, “Effect of lens lesion on neurite outgrowth of retinal ganglion cells in vitro,” Molecular and Cellular Neuroscience, vol. 21, no. 2, pp. 301–311, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Lorber, M. Berry, and A. Logan, “Different factors promote axonal regeneration of adult rat retinal ganglion cells after lens injury and intravitreal peripheral nerve grafting,” The Journal of Neuroscience Research, vol. 86, no. 4, pp. 894–903, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Yin, Q. Cui, Y. Li et al., “Macrophage-derived factors stimulate optic nerve regeneration,” The Journal of Neuroscience, vol. 23, no. 6, pp. 2284–2293, 2003. View at Google Scholar · View at Scopus
  20. M. Berry, Z. Ahmed, B. Lorber, M. Douglas, and A. Logan, “Regeneration of axons in the visual system,” Restorative Neurology and Neuroscience, vol. 26, no. 2-3, pp. 147–174, 2008. View at Google Scholar · View at Scopus
  21. T. G. Hauk, A. Müller, J. Lee, R. Schwendener, and D. Fischer, “Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages,” Experimental Neurology, vol. 209, no. 2, pp. 469–482, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Lorber, M. Berry, M. R. Douglas, T. Nakazawa, and A. Logan, “Activated retinal glia promote neurite outgrowth of retinal ganglion cells via apolipoprotein E,” The Journal of Neuroscience Research, vol. 87, no. 12, pp. 2645–2652, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. C. Kassen, R. Thummel, L. A. Campochiaro, M. J. Harding, N. A. Bennett, and D. R. Hyde, “CNTF induces photoreceptor neuroprotection and Müller glial cell proliferation through two different signaling pathways in the adult zebrafish retina,” Experimental Eye Research, vol. 88, no. 6, pp. 1051–1064, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. T. L. Kent, I. V. Glybina, G. W. Abrams, and R. Iezzi, “Chronic intravitreous infusion of ciliary neurotrophic factor modulates electrical retinal stimulation thresholds in the RCS rat,” Investigative Ophthalmology and Visual Science, vol. 49, no. 1, pp. 372–379, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Bodeutsch, H. Siebert, C. Dermon, and S. Thanos, “Unilateral injury to the adult rat optic nerve causes multiple cellular responses in the contralateral site,” Journal of Neurobiology, vol. 38, pp. 116–128, 1999. View at Google Scholar
  26. R. A. Bush, K. W. Hawks, and P. A. Sieving, “Preservation of inner retinal responses in the aged royal college of surgeons rat: evidence against glutamate excitotoxicity in photoreceptor degeneration,” Investigative Ophthalmology and Visual Science, vol. 36, no. 10, pp. 2054–2062, 1995. View at Google Scholar · View at Scopus