Table of Contents
ISRN Pharmacology
Volume 2013 (2013), Article ID 815094, 8 pages
http://dx.doi.org/10.1155/2013/815094
Research Article

Antiapoptotic Effect of Simvastatin Ameliorates Myocardial Ischemia/Reperfusion Injury

1Pharmacological Department, Medical College, Kufa University, Iraq
2Cardiothoracic Surgical Department, College of Medicine, Kufa University, Iraq
3Biology Department, College of Science, Al-Qadisiyah University, Al-Qadisiyyah, Iraq

Received 15 August 2013; Accepted 18 September 2013

Academic Editors: R. Fantozzi and K. Wada

Copyright © 2013 Najah R. Hadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Dorweiler, D. Pruefer, T. B. Andrasi et al., “Ischemia-reperfusion injury: pathophysiology and clinical implications,” European Journal of Trauma and Emergency Surgery, vol. 33, no. 6, pp. 600–612, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Anselmi, A. Abbate, F. Girola et al., “Myocardial ischemia, stunning, inflammation, and apoptosis during cardiac surgery: a review of evidence,” European Journal of Cardio-Thoracic Surgery, vol. 25, no. 3, pp. 304–311, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Jordan, Z.-Q. Zhao, and J. Vinten-Johansen, “The role of neutrophils in myocardial ischemia-reperfusion injury,” Cardiovascular Research, vol. 43, no. 4, pp. 860–878, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. H. K. Eltzschig and C. D. Collard, “Vascular ischaemia and reperfusion injury,” British Medical Bulletin, vol. 70, pp. 71–86, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Lutz, K. Thürmel, and U. Heemann, “Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation,” Journal of Inflammation, vol. 7, article 27, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. Z.-Q. Zhao, M. Nakamura, N.-P. Wang et al., “Reperfusion induces myocardial apoptotic cell death,” Cardiovascular Research, vol. 45, no. 3, pp. 651–660, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. S. H. Kaufmann and M. O. Hengartner, “Programmed cell death: alive and well in the new millennium,” Trends in Cell Biology, vol. 11, no. 12, pp. 526–534, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Nagata, “Apoptotic DNA fragmentation,” Experimental Cell Research, vol. 256, no. 1, pp. 12–18, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Davignon, “Beneficial cardiovascular pleiotropic effects of statins,” Circulation, vol. 109, no. 23, supplement 1, pp. III39–III43, 2004. View at Google Scholar · View at Scopus
  10. B. V. Naidu, S. M. Woolley, A. S. Farivar, R. Thomas, C. Fraga, and M. S. Mulligan, “Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion,” The Journal of Thoracic and Cardiovascular Surgery, vol. 126, no. 2, pp. 482–489, 2003. View at Google Scholar
  11. A. Undas, M. Celińska-Löwenhoff, M. Kaczor, and J. Musial, “New nonlipid effects of statins and their clinical relevance in cardiovascular disease,” Thrombosis and Haemostasis, vol. 91, no. 6, pp. 1065–1077, 2004. View at Google Scholar · View at Scopus
  12. T. Rajtík, S. Carnická, A. Szobi, L. Mesárošová, M. Máťuš, P. Svec et al., “Pleiotropic effects of simvastatin are associated with mitigation of apoptotic component of cell death upon lethal myocardial reperfusion-induced injury,” Physiological Research, vol. 61, supplement 2, pp. S33–S41, 2012. View at Google Scholar
  13. Y. Wu, X. Yin, C. Wijaya, M.-H. Huang, and B. K. McConnell, “Acute myocardial infarction in rats,” Journal of Visualized Experiments, no. 48, Article ID e2464, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Wiedemann, S. Schneeberger, P. Friedl et al., “The fibrin-derived peptide Bβ15–42 significantly attenuates ischemia-reperfusion injury in a cardiac transplant model,” Transplantation, vol. 89, no. 7, pp. 824–829, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J.-W. Ding, X.-H. Tong, J. Yang et al., “Activated protein C protects myocardium via activation of anti-apoptotic pathways of survival in ischemia-reperfused rat heart,” Journal of Korean Medical Science, vol. 25, no. 11, pp. 1609–1615, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. N. S. Wayman, B. L. Ellis, and C. Thiemermann, “Simvastatin reduces infarct size in a model of acute myocardial ischemia and reperfusion in the rat,” Medical Science Monitor, vol. 9, no. 5, pp. BR155–BR159, 2003. View at Google Scholar · View at Scopus
  17. B. Zingarelli, A. L. Salzman, and C. Szabó, “Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury,” Circulation Research, vol. 83, no. 1, pp. 85–94, 1998. View at Google Scholar · View at Scopus
  18. M. R. Gholami, F. Abolhassani, P. Pasbakhsh et al., “The effects of simvastatin on ischemia-reperfusion injury of sciatic nerve in adult rats,” European Journal of Pharmacology, vol. 590, no. 1–3, pp. 111–114, 2008. View at Google Scholar
  19. A. M. Lefer, B. Campbell, Y.-K. Shin, R. Scalia, R. Hayward, and D. J. Lefer, “Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts,” Circulation, vol. 100, no. 2, pp. 178–184, 1999. View at Google Scholar · View at Scopus
  20. M. Zhang, Y. J. Xu, H. K. Saini, B. Turan, P. P. Liu, and N. S. Dhalla, “Pentoxifylline attenuates cardiac dysfunction and reduces TNF-alpha level in ischemic-reperfusedheart,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 289, no. 2, pp. H832–H839, 2005. View at Publisher · View at Google Scholar
  21. M. Granado, N. Fernández, L. Monge et al., “Effects of coronary ischemia-reperfusion in a rat model of early overnutrition. Role of angiotensin receptors,” PLoS ONE, vol. 8, no. 2, Article ID e54984, 2013. View at Publisher · View at Google Scholar
  22. R. F. Tuma and S. Steffens, “Targeting the endocannabinod system to limit myocardial and cerebral ischemic and reperfusion injury,” Current Pharmaceutical Biotechnology, vol. 13, no. 1, pp. 46–58, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Steffens, F. Montecucco, and F. Mach, “The inflammatoryresponse as a target to reducemyocardial ischaemia and reperfusion injury,” Thrombosis and Haemostasis, vol. 102, no. 2, pp. 240–247, 2009. View at Google Scholar
  24. J. Zhang, X. Cheng, Y.-H. Liao et al., “Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction,” Cardiovascular Drugs and Therapy, vol. 19, no. 1, pp. 13–21, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. F.-Q. Sheng, R. Xu, L.-X. Cheng et al., “In rats with myocardial infarction, interference by simvastatin with the TLR4 signal pathway attenuates ventricular remodelling,” Acta Cardiologica, vol. 64, no. 6, pp. 779–785, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Hajipour, M. H. Somi, F. Saberifar et al., “Simvastatin attenuates intestinal ischaemia/reperfusion-induced injury in rat,” Folia Morphologica, vol. 68, no. 3, pp. 156–162, 2009. View at Google Scholar · View at Scopus
  27. A. C. B. Dantas, F. F. D. A. Batista Jr., L. F. Macedo, M. N. C. Mendes, Í. M. Azevedo, and A. C. Medeiros, “Protective effect of simvastatin in the cyclophosphamide-induced hemohrragic cystitis in rats,” Acta Cirurgica Brasileira, vol. 25, no. 1, pp. 43–46, 2010. View at Google Scholar · View at Scopus
  28. N. R. Veillard, V. Braunersreuther, C. Arnaud et al., “Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages,” Atherosclerosis, vol. 188, no. 1, pp. 51–58, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Bruegel, D. Teupser, I. Haffner, M. Mueller, and J. Thiery, “Statins reduce macrophage inflammatory protein-1α expression in human activated monocytes,” Clinical and Experimental Pharmacology and Physiology, vol. 33, no. 12, pp. 1144–1149, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. H. Cakmak, M. Basar, Y. Seval-Celik et al., “Statins inhibit monocyte chemotactic protein 1 expression in endometriosis,” Reproductive Sciences, vol. 19, no. 6, pp. 572–579, 2012. View at Google Scholar
  31. H.-L. Yang, X.-P. Huang, L. Sun et al., “Effects of simvastatin on cardiac function and serum cardiac troponin I in patients with chronic heart failure,” Modern Medicine & Health 2009-09-005.
  32. M. A. Almansob, B. Xu, L. Zhou et al., “Simvastatin reduces myocardial injury undergoing noncoronary artery cardiac surgery: a randomized controlled trial,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 9, pp. 2304–2313, 2012. View at Google Scholar
  33. J. Veselka, S. Procházková, R. Duchonová, I. Homolová, D. Tesar, and K. A. Bybee, “Preprocedural statin therapy reduces the risk and extent of cardiac biomarker release following percutaneous coronary intervention,” Heart and Vessels, vol. 21, no. 3, pp. 146–151, 2006. View at Publisher · View at Google Scholar
  34. N. A. Abd Elbaky, A. A. Ali, and R. A. Ahmed, “Cardioprotective effect of simvastatin on doxorubicininduced oxidative cardiotoxicity in rats,” Journal of Basic and Applied Sciences, vol. 6, no. 1, pp. 29–38, 2010. View at Google Scholar
  35. S. A. Hamid, H. S. Bower, and G. F. Baxter, “Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium,” American Journal of Physiology–Heart and Circulatory Physiology, vol. 292, no. 6, pp. H2598–H2606, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Slijper, I. Sukhotnik, E. Chemodanov et al., “Effect of simvastatin on intestinal recovery following gut ischemia-reperfusion injury in a rat,” Pediatric Surgery International, vol. 26, no. 1, pp. 105–110, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. F. Dibazar, B. Hajipour, M. M. Hosseinian, M. R. Hemmati, and A. Ghandiha, “Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats,” Folia Morphologica, vol. 67, no. 4, pp. 231–235, 2008. View at Google Scholar · View at Scopus
  38. M. L. Ko, C. F. Chen, P. H. Peng, and Y. H. Peng, “Simvastatin upregulates Bcl-2 expression and protects retinal neurons from early ischemia/reperfusion injury in the rat retina,” Experimental Eye Research, vol. 93, no. 5, pp. 580–585, 2011. View at Google Scholar