Genotoxicological Evaluation of NUTRALYS Pea Protein Isolate

Table 5

Summary of micronucleus assay.

Group/dose	Treatment/sacrifice	Total PCE scored		Total NCE scored		PCE : NCE		Total MN-PCE scored		%MN-PCE  Mean ± SD
	Time point	M	F	M	F	M	F	M	F	M	F
G1; millipore; water	Single/24 h; Single/48 h; Two day/24 h*	563; 569; 528	501; 511; 490	437; 431; 472	499; 489; 510	1.30; 1.34; 1.14	1.01; 1.05; 0.98	10; 11; 16	12; 10; 13	0.10±0.08; 0.11±0.05; 0.16±0.04	0.12±0.08; 0.10±0.04; 0.13±0.08
G2; 2000 mg/kg; b.w.	Single/24 h; Single/48 h; Two day/24 h*	541; 563; 520	539; 555; 483	459; 437; 480	461; 445; 517	1.18; 1.31; 1.09	1.18; 1.26; 0.94	10; 15; 15	12; 14; 15	0.10±0.05; 0.15±0.08; 0.15±0.07	0.12±0.06; 0.14±0.04; 0.15±0.04
G3; 40 mg/kg b.w.; CYP	Single/24 h	506	528	494	472	1.04	1.13	92	80	0.92±0.18	0.80±0.22

24 h*: Following last administration; M: male; F: female; CYP: cyclophosphamide (monohydrate); PCE: polychromatic erythrocyte; NCE: normochromatic erythrocyte; MN-PCE: micronucleated polychromatic erythrocyte.