In Vivo Effect of Arsenic Trioxide on Keap1-p62-Nrf2 Signaling Pathway in Mouse Liver: Expression of Antioxidant Responsive Element-Driven Genes Related to Glutathione Metabolism
Figure 2
Changes in liver histology. Microphotographs of liver sections (6 μm) stained with hematoxylin and eosin (HE). The original magnification: ×400. (a) Normal histological appearance of liver tissue of control mice, central vein (CV). (b) Group II: vacuolar degenerations (thin arrows), sinusoidal dilation (thick arrow), (c) Group III: disruption of epithelium lining (short thick arrows) of the central vein, vacuolar degenerations (thin arrows). (d) Group IV: vacuolar degeneration (thin arrow), loss of integrity in epithelium lining of the central vein (short thick arrow), and loss of typical hepatic cords organization. (e) Group V: extensive degeneration of epithelial lining of the central vein (thick arrow), loss of typical hepatic cord organization, hepatocellular degradation, and infiltration of the nucleus into the central vein (thin arrow).
