Carbofuran Induced Oxidative Stress in Rat Heart: Ameliorative Effect of Vitamin C

Table 5

Effect of carbofuran and vitamin C on antioxidant enzymes in heart tissues.

Activity of antioxidative enzymes	Activity of SOD^a	Activity of catalase^a	Activity of GST^b
Control	7.49±0.69	1.54±0.18	111.3±4.65
5% CF	6.14±0.51^∗ (−18.1%)	1.19±0.08^∗∗ (−22.7%)	96.75±5.56^∗ (−13%)
10% CF	4.72±0.69^∗∗∗ (−36.98%)	0.9950±0.08^∗∗∗ (−35.3%)	71.00±8.33^∗∗∗ (−36%)
Vit C	7.79±0.614^ns	1.59±0.07^ns	112.5±4.041^ns
Vit C + 5% CF	7.37±0.72^ns	1.33±0.12^ns	103.0±6.78^ns
Vit C + 10% CF	5.89±0.841^ns	1.28±0.11^ns	97.75±5.25^ns

aIU mg⁻¹ protein, ^b𝜇mole mL⁻¹ min⁻¹ mg⁻¹ protein; the (−) sign shows decrease in the activity. The values are mean ± SD of five independent experiments. The procedures for estimation of the activities of the enzymes were as mentioned in Section 2. *, **, and *** indicate the 𝑃 values significance at <0.05, <0.01, and <0.001, respectively. ns: nonsignificant at 𝑃>0.05 as compared to control.