Differential Effects on Survival, Humoral Immune Responses and Brain Lesions in Inbred BALB/C, CBA/CA, and C57BL/6 Mice Experimentally Infected with Neospora caninum Tachyzoites

Table 1

IgG2a or IgG2c and IgG1 titres were measured at the time of death or euthanasia (intercurrent death) or at the end of the experiment at day 34 PI. For calculation, the value “4.5” was chosen when the titre was below the detection limit (<5.0).

Experimental groups				Antibodies at day 34 or time of euthanization (2log)
		Mouse number	Survival time (days)
Inbred strain	Challenge dose			IgG2a/c	IgG1	IgG2a/c-IgG1
		1.1	34	13.6	11.2	2.4
		1.2	34	14.1	11.0	3.1
BALB/c	1 × 10^6	1.3	34	13.0	11.6	1.4
		1.4	34	14.1	14.4	−0.3
		1.5	34	14.7	15.4	−0.7
		2.1	34	14.6	14.6	0.0
		2.2	34	14.8	15.8	−1.0
BALB/c	5 × 10^6	2.3	34	14.5	14.7	−0.2
		2.4	23	14.4	13.3	1.1
		2.5	23	15.0	14.0	1.0
		3.1	8	—	—	—
		3.2	12	—	—	—
BALB/c	25 × 10^6	3.3	8	9.9	7.7	2.2
		3.4	12	9.4	8.3	1.1
		3.5	7	—	—	—
		4.1	34	10.8	4.5	6.3
		4.2	34	14.8	6.5	8.3
CBA/Ca	1 × 10^6	4.3	34	11.0	6.7	4.3
		4.4	34	11.2	4.5	6.7
		4.5	34	13.9	9.8	4.1
		5.1	34	12.2	6.0	6.2
		5.2	34	13.1	5.1	8.0
CBA/Ca	5 × 10^6	5.3	34	13.3	9.2	4.1
		5.4	34	13.5	9.6	3.9
		5.5	34	13.6	12.2	1.4
		6.1	9	5.0	4.5	0.5
		6.2	9	6.0	6.9	−0.9
CBA/Ca	25 × 10^6	6.3	8	—	—	—
		6.4	9	5.7	4.5	1.2
		6.5	9	4.5	4.5	0.0
		7.1	34	13.4	9.8	3.6
		7.2	34	14.9	14.6	0.3
C57BL/6	1 × 10^6	7.3	29	14.1	10.8	3.3
		7.4	29	12.9	7.1	5.8
		7.5	34	14.6	9.2	5.4
		8.1	13	10.1	4.5	5.6
		8.2	7	4.5	4.5	0.0
C57BL6	5 × 10^6	8.3	34	15.6	13.4	2.2
		8.4	8	10.5	4.5	6.0
		8.5	34	16.5	13.7	2.8
		9.1	8	10.7	6.9	3.8
		9.2	8	7.4	4.5	2.9
C57BL6	25 × 10^6	9.3	34	15.6	14.5	1.1
		9.4	8	7.7	4.5	3.2
		9.5	8	8.5	4.5	4.0