International Scholarly Research Notices / 2013 / Article / Fig 1

Research Article

Depressed-Type Colonic Lesions and “De Novo” Cancer in Familial Adenomatous Polyposis: A Colonoscopist’s Viewpoint

Figure 1

“Adenoma-carcinoma sequence” and “de novo” theory regarding the development/progression of colorectal neoplasms. In the adenoma-carcinoma sequence, lesions grow and protrude and finally develop to ulceration; this is called the “mountain route.” Depressed-type lesions develop by the de novo pathway. This is called the “direct route.”

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