Research Article

Formulation Development and Evaluation of Drug Release Kinetics from Colon-Targeted Ibuprofen Tablets Based on Eudragit RL 100-Chitosan Interpolyelectrolyte Complexes

Table 1

Physicochemical properties of the tablets.

Formulation codeAverage friability (%) Mean weight (mg) Mean crushing strength (kgf) Average disintegration time (min)

CS : EL (1 : 1)
CS : EL (2 : 3)
CS : EL (3 : 2)
EL

Mean ± SD, n = 20, #n = 3, and n = 10.
CS : EL (1 : 1): tablets coated with IPEC containing 50% chitosan and 50% Eudragit RL 100.
CS : EL (2 : 3): tablets coated with IPEC containing 40% chitosan and 60% Eudragit RL 100.
CS : EL (3 : 2): tablets coated with IPEC containing 60% chitosan and 40% Eudragit RL 100.
EL: control tablets coated with IPEC containing only Eudragit RL 100.