Formulation Development and Evaluation of Drug Release Kinetics from Colon-Targeted Ibuprofen Tablets Based on Eudragit RL 100-Chitosan Interpolyelectrolyte Complexes

Table 2

The various release models and their release parameters.

Batch code	Higuchi		Zero-order		First-order		Ritger-Peppas
	𝐾𝐻	𝑅^2	𝐾0	𝑅^2	𝐾𝐹	𝑅^2	𝑁	𝑅^2
CS : EL (1 : 1)	14.72	0.888	9.68	0.996	−0.13	0.918	1.12	0.763
CS : EL (2 : 3)	26.90	0.917	13.59	0.997	−0.20	0.731	1.16	0.825
CS : EL (3 : 2)	34.18	0.837	10.46	0.999	−0.09	0.816	1.05	0.855
EL	19.57	0.831	6.82	0.995	−0.05	0.777	1.10	0.773

𝐾₀: zero-order release rate constant; 𝐾₁: first-order release rate constant; 𝐾_𝐻: higuchi release rate constant; 𝑅²: regression line value; n: Ritger-Peppas value.
CS : EL (1 : 1): tablets coated with IPEC containing 50% chitosan and 50% Eudragit RL 100.
CS : EL (2 : 3): tablets coated with IPEC containing 40% chitosan and 60% Eudragit RL 100.
CS : EL (3 : 2): tablets coated with IPEC containing 60% chitosan and 40% Eudragit RL 100.
EL: control tablets coated with IPEC containing only Eudragit RL 100.