Inhibition of Endoplasmic Reticulum Stress and Atherosclerosis by 2-Aminopurine in Apolipoprotein E-Deficient Mice

Table 1

Mouse body weights and plasma lipids.

	Body weight; (g)	Food intake; (g/g BW/day)	Plasma cholesterol; (mg/dL)	Plasma triglycerides; (mg/dL)
Control	27.8±0.5	0.25±0.07	513±29	146±18
2-AP	26.9±0.9	0.24±0.03	530±39	147±17

Male apoE ^−/− mice at 6 weeks of age were gavage-fed 200 μl water (control) or 200 mg/kg BW of 2-AP once every other day for 24 weeks. Body weight and food intake were monitored by weighing the animals and food weekly. Data presented are the final body weights at the end of the experiment and the average of food intake over 24 weeks. Blood samples were obtained from apoE ^−/− mice gavage-fed with 2-AP or water alone (control). Plasma total triglycerides and total cholesterol were determined as described in Materials and Methods. Values represent the mean SEM of 12 mice.