Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems

<table>Schematic diagram of intestinal drug transport from lipid-based formulations via the portal and the mesenteric lymphatic routes. (A) Increased membrane fluidity facilitating transcellular absorption. (B) Opening of tight junctions to allow paracellular transport. (C) Inhibition of P-gp and/or CYP450 to increase intracellular concentration and residence time. (D) Stimulation of lipoprotein/chylomicron production. ABL: aqueous boundary layer; D: drug; D−: ionized drug substance; FA: fatty acid; LCFA: long chain fatty acid; ME: microemulsion; MG: monoglyceride; SEDDS: self-emulsifying drug delivery system; TG, triglyceride; TJ, tight junction.</table>

International Scholarly Research Notices

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Figure 1

Figure 1: Formulation Strategies to Improve the Bioavailability of Poorly Absorbed Drugs with Special Emphasis on Self-Emulsifying Systems 