Table of Contents
ISRN Dermatology
Volume 2013 (2013), Article ID 856541, 8 pages
http://dx.doi.org/10.1155/2013/856541
Review Article

Extravasation Injuries in Adults

Department of Burns and Plastic Surgery, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK

Received 28 February 2013; Accepted 2 April 2013

Academic Editors: D. T. Alexandrescu, A. Belloni-Fortina, and F. Guarneri

Copyright © 2013 S. Al-Benna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. E. MacCara, “Extravasation. A hazard of intravenous therapy,” Drug Intelligence and Clinical Pharmacy, vol. 17, no. 10, pp. 713–717, 1983. View at Google Scholar · View at Scopus
  2. A. M. Jones and A. Stanley, “Probe High Extravasation Rates. An investigation of extravasation in City Hospital NHS Trust, Birmingham,” The National Extravasation Information Service, http://www.extravasation.org.uk/probe.htm.
  3. J. E. Utting, “Pitfalls in anaesthetic practice,” British Journal of Anaesthesia, vol. 59, no. 7, pp. 877–890, 1987. View at Google Scholar · View at Scopus
  4. J. J. Wang, E. Cortes, L. F. Sinks, and J. F. Holland, “Therapeutic effect and toxicity of adriamycin in patients with neoplastic disease,” Cancer, vol. 28, no. 4, pp. 837–843, 1971. View at Google Scholar · View at Scopus
  5. D. Gault and J. Challands, “Extravasation of Drugs,” in Anaesthesia Review, L. Kaufman and R. Ginsburg, Eds., vol. 13, Churchill Livingstone, Edinburgh, UK, 1997. View at Google Scholar
  6. A. S. Brown, D. J. Hoelzer, and S. A. Piercy, “Skin necrosis from extravasation of intravenous fluids in children,” Plastic and Reconstructive Surgery, vol. 64, no. 2, pp. 145–150, 1979. View at Google Scholar · View at Scopus
  7. A. L. Garden and P. C. Laussen, “An unending supply of “unusual” complications from central venous catheters,” Paediatric Anaesthesia, vol. 14, no. 11, pp. 905–909, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. R. Smith, “Prevention and treatment of extravasation,” British Journal of Parenteral Therapy, vol. 6, no. 5, pp. 114–118, 1985. View at Google Scholar · View at Scopus
  9. G. Bertelli, “Prevention and management of extravasation of cytotoxic drugs,” Drug Safety, vol. 12, no. 4, pp. 245–255, 1995. View at Google Scholar · View at Scopus
  10. A. S. Brown, D. J. Hoelzer, and S. A. Piercy, “Skin necrosis from extravasation of intravenous fluids in children,” Plastic and Reconstructive Surgery, vol. 64, no. 2, pp. 145–150, 1979. View at Google Scholar · View at Scopus
  11. I. Hawley, “Statistics from the National Extravasation Information Service green card reporting database,” 1987–2006, http://www.extravasation.org.uk/stats.htm.
  12. L. S. Wood and S. M. Gullo, “IV vesicants: how to avoid extravasation,” American Journal of Nursing, vol. 93, no. 4, pp. 42–46, 1993. View at Google Scholar · View at Scopus
  13. S. M. Shenaq, E. H. A. Abbase, and J. D. Friedman, “Soft-tissue reconstruction following extravasation of chemotherapeutic agents,” Surgical Oncology Clinics of North America, vol. 5, no. 4, pp. 825–845, 1996. View at Google Scholar · View at Scopus
  14. J. Shapiro and G. E. Richardson, “Paclitaxel-induced “recall” soft tissue injury occurring at the site of previous extravasation with subsequent intravenous treatment in a different limb,” Journal of Clinical Oncology, vol. 12, no. 10, pp. 2237–2238, 1994. View at Google Scholar · View at Scopus
  15. D. S. Alberts and R. T. Dorr, “Case report: topical DMSO for mitomycin-C-induced skin ulceration,” Oncology Nursing Forum, vol. 18, no. 4, pp. 693–695, 1991. View at Google Scholar · View at Scopus
  16. S. S. Donaldson, J. M. Glick, and J. R. Wilbur, “Adriamycin activating a recall phenomenon after radiation therapy,” Annals of Internal Medicine, vol. 81, no. 3, pp. 407–408, 1974. View at Google Scholar · View at Scopus
  17. D. Baer and S. Wilkinson, “Daunomycin, adriamycin, and recall effect,” Annals of Internal Medicine, vol. 85, pp. 259–260, 1975. View at Google Scholar
  18. M. E. Gil and J. Mateu, “Treatment of extravasation from parenteral nutrition solution,” Annals of Pharmacotherapy, vol. 32, no. 1, pp. 51–55, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. J. L. Chen and M. O'Shea, “Extravasation injury associated with low-dose dopamine,” Annals of Pharmacotherapy, vol. 32, no. 5, pp. 545–548, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. M. P. Federle, P. J. Chang, S. Confer, and B. Ozgun, “Frequency and effects of extravasation of ionic and nonionic CT contrast media during rapid bolus injection,” Radiology, vol. 206, no. 3, pp. 637–640, 1998. View at Google Scholar · View at Scopus
  21. E. Kassner, “Evaluation and treatment of chemotherapy extravasation injuries,” Journal of Pediatric Oncology Nursing, vol. 17, no. 3, pp. 135–148, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. D. F. Brown, M. J. Muirhead, P. M. Travis et al., “Mode of chemotherapy does not affect complications with an implantable venous access device,” Cancer, vol. 80, no. 5, pp. 966–972, 1997. View at Google Scholar
  23. T. Kerrison and J. Woodhull, “Reducing the risk of thrombophebitis: comparison of Teflon and Vialon cannulae,” Professional Nurse London, vol. 9, pp. 662–662, 1994. View at Google Scholar
  24. T. Modena, B. Conti, I. Genta et al., “Hyaluronidase-injectable microparticles intended for the treatment of extravasation,” Journal of Microencapsulation, vol. 15, no. 1, pp. 85–92, 1998. View at Google Scholar · View at Scopus
  25. R. J. Ignoffo and M. A. Friedman, “Therapy of local toxicities caused by extravasation of cancer chemotherapeutic drugs,” Cancer Treatment Reviews, vol. 7, no. 1, pp. 17–27, 1980. View at Google Scholar · View at Scopus
  26. E. A. Khan, A. G. Correa, and C. J. Baker, “Suppurative thrombophlebitis in children: a ten-year experience,” Pediatric Infectious Disease Journal, vol. 16, no. 1, pp. 63–67, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Subhani, S. Sridhar, and J. D. DeCristofaro, “Phentolamine use in a neonate for the prevention of dermal necrosis caused by dopamine: a case report,” Journal of Perinatology, vol. 21, no. 5, pp. 324–326, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. C. E. Wilkins and A. J. B. Emmerson, “Extravasation injuries on regional neonatal units,” Archives of Disease in Childhood, vol. 89, no. 3, pp. F274–F275, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. W. S. Susser, D. L. Whitaker-Worth, and J. M. Grant-Kels, “Mucocutaneous reactions to chemotherapy,” Journal of the American Academy of Dermatology, vol. 40, no. 3, pp. 367–398, 1999. View at Google Scholar · View at Scopus
  30. M. J. Soble, R. T. Dorr, P. Plezia, and S. Breckenridge, “Dose-dependent skin ulcers in mice treated with DNA binding antitumor antibiotics,” Cancer Chemotherapy and Pharmacology, vol. 20, no. 1, pp. 33–36, 1987. View at Google Scholar · View at Scopus
  31. M. Garnick, M. Israel, V. Khetarpal, and J. Luce, “Persistence of anthracycline levels following dermal and subcutaneous adriamycin extravasation,” Proceedings of the American Association for Cancer Research, vol. 22, p. 685, 1981. View at Google Scholar · View at Scopus
  32. J. Bhawan, J. Petry, and M. E. Rybak, “Histologic changes induced in skin by extravasation of doxorubicin (adriamycin),” Journal of Cutaneous Pathology, vol. 16, no. 3, pp. 158–163, 1989. View at Google Scholar · View at Scopus
  33. P. Berghammer, R. Pöhnl, M. Baur, and C. Dittrich, “Docetaxel extravasation,” Supportive Care in Cancer, vol. 9, no. 2, pp. 131–134, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. R. Rudolph and D. L. Larson, “Etiology and treatment of chemotherapeutic agent extravasation injuries: a review,” Journal of Clinical Oncology, vol. 5, no. 7, pp. 1116–1126, 1987. View at Google Scholar · View at Scopus
  35. C. Sauerland, C. Engelking, R. Wickham, and D. Corbi, “Vesicant extravasation Part I: mechanisms, pathogenesis, and nursing care to reduce risk,” Oncology Nursing Forum, vol. 33, no. 6, pp. 1134–1141, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. S. E. Zimmet, “The prevention of cutaneous necrosis following extravasation of hypertonic saline and sodium tetradecyl sulfate,” Journal of Dermatologic Surgery and Oncology, vol. 19, no. 7, pp. 641–646, 1993. View at Google Scholar · View at Scopus
  37. D. T. Gault, “Extravasation injuries,” British Journal of Plastic Surgery, vol. 46, no. 2, pp. 91–96, 1993. View at Google Scholar
  38. V. K. Rao, P. D. Feldman, and D. G. Dibbell, “Extravasation injury to the hand by intravenous phenytoin: report of three cases,” Journal of Neurosurgery, vol. 68, no. 6, pp. 967–969, 1988. View at Google Scholar · View at Scopus
  39. B. K. Siwy and A. M. Sadove, “Acute management of dopamine infiltration injury with Regitine,” Plastic and Reconstructive Surgery, vol. 80, no. 4, pp. 610–612, 1987. View at Google Scholar · View at Scopus
  40. R. J. Kumar, S. P. Pegg, and R. M. Kimble, “Management of extravasation injuries,” ANZ Journal of Surgery, vol. 71, no. 5, pp. 285–289, 2001. View at Google Scholar · View at Scopus
  41. P. A. Harris, S. Bradley, and A. L. H. Moss, “Limiting the damage of iatrogenic extravasation injury in neonates,” Plastic and Reconstructive Surgery, vol. 107, no. 3, pp. 893–894, 2001. View at Google Scholar · View at Scopus
  42. J. Friedman, “Plastic surgical problems in the neonatal intensive care unit,” Clinics in Plastic Surgery, vol. 25, no. 4, pp. 599–617, 1998. View at Google Scholar · View at Scopus
  43. P. A. Falcone, D. T. Barrall, D. R. Jeyarajah, and J. A. I. Grossman, “Nonoperative management of full-thickness intravenous extravasation injuries in premature neonates using enzymatic debridement,” Annals of Plastic Surgery, vol. 22, no. 2, pp. 146–149, 1989. View at Google Scholar · View at Scopus
  44. K. E. Zenk, I. Dungy, and G. R. Greene, “Nafcillin extravasation injury. Use of hyaluronidase as an antidote,” American Journal of Diseases of Children, vol. 135, no. 12, pp. 1113–1114, 1981. View at Google Scholar · View at Scopus
  45. N. Scuderi and M. G. Onesti, “Antitumor agents: extravasation, management, and surgical treatment,” Annals of Plastic Surgery, vol. 32, no. 1, pp. 39–44, 1994. View at Google Scholar · View at Scopus
  46. R. G. Dufresne, “Skin necrosis from intravenously infused materials,” Cutis, vol. 39, no. 3, pp. 197–198, 1987. View at Google Scholar · View at Scopus
  47. G. Bertelli, D. Dini, G. B. Forno et al., “Hyaluronidase as an antidote to extravasation of vinca alkaloids: clinical results,” Journal of Cancer Research and Clinical Oncology, vol. 120, no. 8, pp. 505–506, 1994. View at Publisher · View at Google Scholar · View at Scopus
  48. K. A. Denkler and B. E. Cohen, “Reversal of dopamine extravasation injury with topical nitroglycerin ointment,” Plastic and Reconstructive Surgery, vol. 84, no. 5, pp. 811–813, 1989. View at Google Scholar · View at Scopus
  49. S. J. Phelps and R. A. Helms, “Risk factors affecting infiltration of peripheral venous lines in infants,” Journal of Pediatrics, vol. 111, no. 3, pp. 384–389, 1987. View at Google Scholar · View at Scopus
  50. R. Lauvin, L. Miglianico, and R. Hellegouarc'h, “Skin cancer occurring 10 years after the extravasation of doxorubicin,” New England Journal of Medicine, vol. 332, no. 11, p. 754, 1995. View at Publisher · View at Google Scholar · View at Scopus
  51. D. A. Millam, “Managing complication of i.v. therapy,” Nursing, vol. 18, pp. 34–43, 1988. View at Google Scholar
  52. J. Davies, D. Gault, and R. Buchdahl, “Preventing the scars of neonatal intensive care,” Archives of Disease in Childhood, vol. 70, no. 1, pp. F50–F51, 1994. View at Google Scholar · View at Scopus
  53. P. S. Shah, E. Ng, and A. K. Sinha, “Heparin for prolonging peripheral intravenous catheter use in neonates,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD002774, 2005. View at Google Scholar · View at Scopus
  54. R. A. Ener, S. B. Meglathery, and M. Styler, “Extravasation of systemic hemato-oncological therapies,” Annals of Oncology, vol. 15, no. 6, pp. 858–862, 2004. View at Publisher · View at Google Scholar · View at Scopus
  55. F. R. Heckler, “Current thought on extravasation injuries,” Clinics in Plastic Surgery, vol. 16, pp. 557–563, 1989. View at Google Scholar