Table of Contents
ISRN Endocrinology
Volume 2013, Article ID 858690, 8 pages
Research Article

The Effect of Pioglitazone on Antioxidant Levels and Renal Histopathology in Streptozotocin-Induced Diabetic Rats

1Department of Internal Medicine, Manisa Government Hospital, 45000 Manisa, Turkey
2Division of Endocrinology, Department of Internal Medicine, Adnan Menderes University Medical Faculty, 09100 Aydin, Turkey
3Department of Medical Biochemistry, Adnan Menderes University Medical Faculty, 09100 Aydin, Turkey
4Department of Pathology, Adnan Menderes University Medical Faculty, 09100 Aydin, Turkey

Received 21 February 2013; Accepted 7 April 2013

Academic Editors: B. Larijani and V. Pezzi

Copyright © 2013 Munire Kuru Karabas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Diabetic nephropathy is the most commonly seen cause of chronic renal failure, and oxidative stress is important in etiology. In the present study, favorable effects (if any) of the treatment with a thiazolidinedione group drug, pioglitazone, on antioxidant enzyme levels in the renal tissue, renal histopathology, and inflammatory cytokine levels have been investigated. Method. Forty male Wistar rats were divided into 4 groups as the control, diabetic control, and 10 and 30 mg pioglitazone-administered diabetic groups. After 4 weeks, antioxidant enzyme levels in renal tissues and inflammatory markers were investigated. Results. Blood glucose levels did not differ between the diabetic control and drug-administered groups. In pioglitazone-administered rats, histopathological findings such as tubular dilation, necrotic tubular epithelium, glomerular focal necrosis, and vascular consolidation were observed at a lesser extent than the diabetic control group. Any difference was not detected between the diabetic groups with respect to the levels of malondialdehyde, superoxide dismutase, catalase, glutathione, nitric oxide, interleukin-6, and tumor necrosis factor-alpha. Conclusion. Pioglitazone regressed development of histopathological lesions such as glomerular focal necrosis, tubular epithelial necrosis, tubular dilation, and vascular wall consolidation. However, any favorable effect on antioxidant enzyme levels in renal tissues and inflammation markers was not detected.