Table of Contents
ISRN Nephrology
Volume 2013, Article ID 865164, 6 pages
http://dx.doi.org/10.5402/2013/865164
Clinical Study

NGAL Usefulness in the Intensive Care Unit Three Hours after Cardiac Surgery

1Department of Intensive Care, CHR Citadelle, Boulevard du 12ème de ligne 1, 4000 Liège, Belgium
2Department of Laboratory Medicine, CHR Citadelle, Boulevard du 12ème de ligne 1, 4000 Liège, Belgium
3Department of Nephrology, CHR Citadelle, Boulevard du 12ème de ligne 1, 4000 Liège, Belgium

Received 17 September 2012; Accepted 2 October 2012

Academic Editors: J. Almirall and A. Meseguer

Copyright © 2013 Geoffray Delcroix et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Neutrophil gelatinase-associated lipocalin (NGAL) measured by a research ELISA is described as an early marker of acute kidney injury (AKI). The aim of this study is to define the usefulness of plasma NGAL (pNGAL) and urine NGAL (uNGAL) measured with platform analysers to detect AKI 3 hours after cardiac surgery in fifty adult patients. Methods and Main Results. pNGAL and uNGAL were measured before and 3 hours after cardiac surgery. AKI, defined following the acute kidney injury network definition, was observed in 17 patients. pNGAL was >149 ng/mL in 8 patients with AKI, two of them died in the follow-up. We also observed elevated pNGAL in 8 patients without AKI. Only one uNGAL was >132 ng/mL among the 15 AKI patients. Sensitivity of pNGAL for prediction of AKI is 47% and specificity is 75.7%. The positive likelihood ratio (LR+) is 1.9 and negative likelihood ratio (LR−) is 0.7. uNGAL performance is slightly improved when reported to urinary creatinine. Following this study, a ratio >62 ng/mg assure a sensitivity of 66.6% and a specificity of 78.5%. LR+ is 3 and a LR− is, 0.42. Conclusions. Three hours after cardiac surgery, pNGAL predicts AKI with a low sensitivity and specificity.