Evaluation of Packed-Bed Reactor and Continuous Stirred Tank Reactor for the Production of Colchicine Derivatives

Table 1

Design matrix generated by DoE showing response of each run.

Run	A Dissolved oxygen (%)	B Colchicine (g/L)	C Process time (h)	Predicted 3-DMC (g/L)
1	50.00	5.00	48.00	4.32
2	32.50	7.50	39.00	4.60
3	32.50	7.50	39.00	4.60
4	15.00	5.00	48.00	1.45
5	32.50	7.50	39.00	4.60
6	32.50	7.50	39.00	4.60
7	32.50	11.70	39.00	3.18
8	32.50	7.50	39.00	4.60
9	32.50	7.50	39.00	4.60
10	50.00	10.00	30.00	4.60
11	32.50	7.50	54.14	5.10
12	15.00	10.00	48.00	2.74
13	50.00	10.00	48.00	7.90
14	32.50	3.30	39.00	2.43
15	61.93	7.50	39.00	5.95
16	15.00	10.00	30.00	0.91
17	15.00	5.00	30.00	1.12
18	3.07	7.50	39.00	0.67
19	32.50	7.50	23.86	2.04
20	50.00	5.00	30.00	3.10