Research Article

Generation of Constitutive Active ERK Mutants as Tools for Cancer Research in Zebrafish

Table 6

Cluster 6 gene ontology.

PeptideName proteinFunctions

RBL2_655_667Retinoblastoma-like protein 2.p130.PRB2. RBR-2 Tumor suppressor, inhibitor of E2F-mediated transactivation, cell cycle regulation and proliferation, differentiation during human placental development

PRKDC_2618_2630DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNPK1.p350Apoptosis (FAS signaling pathway) Cell Cycle: G2/M Checkpoint, B-cell differentiation, telomere maintenance, DNA double strand break repair, transcription factor

PP2AB_297_309Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform. PP2A-beta. PPP2CB. PPM1B Fibroblast growth factor receptor signaling pathway, negative regulation of Ras protein signal transduction, negative regulation of apoptotic process, proteasomal ubiquitin-dependent protein catabolic process

MBP_222_234Myelin basic protein. Myelin A1 protein. Myelin membraneencephalitogenic protein Protease binding, immune response, synaptic transmission, structural constituent of myelin sheath

NEK3_158_170NimA-related protein kinase 3. HSPK 36 Protein serine/threonine kinase activity, cell cycle, mitosis, cell division

KCC2G_278_289Calcium/calmodulin-dependent protein kinase type II gamma chain. CaM kinase II subunit gamma, CaMK-II subunit gamma. CAMK2GG1/S transition of mitotic cell cycle, response to hypoxia, synaptic transmission, cytokine-mediated signaling pathway, insulin secretion

CGHB_109_121Choriogonadotropin subunit beta precursor. CGB5. HCG. CG-betaHormone-mediated signaling pathway

CDC2_154_169Cell division control protein 2 homolog.p34 protein kinase. Cyclin-dependent kinase 1. CDK1. CDC28A. P34CDC2 Cell cycle checkpoint, G1/S transition of mitotic cell cycle, MAPK cascade activation, microtubule cytoskeleton organization, toll-like receptor signaling pathway, cyclin-dependent protein kinase activity, spindle microtubule, DNA replication, DNA repair protein complex assembly, apoptotic process, DNA damage checkpoint, epidermal growth factor receptor signaling pathway, Ras protein signal transduction, pronuclear fusion, axon guidance, cell aging, insulin receptor signaling pathway, RNA polymerase II carboxy-terminal domain kinase activity, fibroblast growth factor receptor signaling pathway, gene expression, regulation of Schwann cell