Table of Contents
ISRN Anatomy
Volume 2013, Article ID 870721, 6 pages
Research Article

Luteinizing Hormone-Releasing Hormone Distribution in the Anterior Hypothalamus of the Female Rats

1Departamento de Anatomía, Facultad de Medicina, Universidad de La Laguna, Ofra s/n, 38071 La Laguna, Tenerife, Spain
2Departamento de Farmacología, Facultad de Medicina, Universidad de La Laguna, Ofra s/n, 38071 La Laguna, Tenerife, Islas Canarias, Spain
3Departamento de Biotecnología, Instituto de Investigación y Ciencias de Puerto del Rosario, c/Tenerife 35, 35600 Puerto del Rosario, Fuerteventura, Isla Canarias, Spain

Received 20 February 2013; Accepted 17 April 2013

Academic Editors: Y. Aurell and T. Nohno

Copyright © 2013 Leandro Castañeyra-Ruiz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Luteinizing hormone-releasing hormone (LHRH) neurons and fibers are located in the anteroventral hypothalamus, specifically in the preoptic medial area and the organum vasculosum of the lamina terminalis. Most luteinizing hormone-releasing hormone neurons project to the median eminence where they are secreted in the pituitary portal system in order to control the release of gonadotropin. The aim of this study is to provide, using immunohistochemistry and female brain rats, a new description of the luteinizing hormone-releasing hormone fibers and neuron localization in the anterior hypothalamus. The greatest amount of the LHRH immunoreactive material was found in the organum vasculosum of the lamina terminalis that is located around the anterior region of the third ventricle. The intensity of the reaction of LHRH immunoreactive material decreases from cephalic to caudal localization; therefore, the greatest immunoreaction is in the organum vasculosum of the lamina terminalis, followed by the dorsomedial preoptic area, the ventromedial preoptic area, and finally the ventrolateral medial preoptic area, and in fibers surrounding the suprachiasmatic nucleus and subependymal layer on the floor of the third ventricle where the least amount immunoreactive material is found.