Table of Contents
ISRN Gastroenterology
Volume 2013, Article ID 871308, 5 pages
Research Article

The Incidence of Colorectal Cancer Is Decreasing in the Older Age Cohorts in the Zaanstreek Region in the Netherlands: An Age-Cohort Effect

1Department of Internal Medicine, Zaans Medisch Centrum, 210 1500 EE Zaandam, The Netherlands
2Department of Gastroenterology, Zaans Medisch Centrum, 210 1500 EE Zaandam, The Netherlands
3Department of Pathology, Zaans Medisch Centrum, 210 1500 EE Zaandam, The Netherlands

Received 23 April 2013; Accepted 15 May 2013

Academic Editors: L. J. Hofseth, V. Kate, and I. Takeyoshi

Copyright © 2013 R. J. L. F. Loffeld et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Colorectal cancer (CRC) has a high incidence. Removal of adenomas, the precursor lesion, could be helpful in the prevention of cancer. Aim. To investigate the yearly incidence of CRC in consecutive years. Patients and Methods. All patients diagnosed with CRC in the years 1990 till 2010 were studied. Date of diagnosis, age at time of diagnosis, gender, and localisation of the tumour were assessed. Results. A total of 1575 incident CRC were diagnosed, 865 men (55%) and 710 women (45%). CRC occurred more often in men. In the course of the years, the occurrence of CRC increased. After exclusion of rectal cancer, the percentage of proximal cancer in the colon shows a trend towards increase in the consecutive years. In the twenty consecutive years, the population of the Zaanstreek region increased from 130.000 to 145.330. There was a significant increase of CRC in the age cohort 51–70 in the period of twenty years, while a significant decreasing incidence of cancer was seen in patients above 71 years. Conclusion. The decreasing incidence of colorectal cancer in the age cohorts above 71 years possibly reflects indirect evidence of an age-cohort effect due to removal of adenomas in these age cohorts earlier in life.