Antiallergic and Antiarthritic Effects of Stem Bark Extract of Glyphaea brevis (Spreng) Monachino (Tiliaceae) in Murine Models
Figure 1
Effect of G. brevis extract (GBE) on carrageenan-induced oedema in mice. ICR mice (25–30 g) were injected with 50 μL of a 1% carrageenan suspension into the subplantar tissue of the right hind paw. Oedema was monitored at 1 h intervals over 6 h as percentage increase in paw thickness (a and c), and total oedema induced during the 6 h was calculated as area under the time course curves, AUC (b and d). Drug effects were evaluated by comparing the maximal and total oedema responses attained during 6 h in drug-treated groups with the corresponding values attained in drug vehicle-treated inflamed control groups. In the preventive (prophylactic) protocol (left panel), drug-vehicle, GBE 30, 100, and 300 mg kg−1, and aspirin 100 mg kg−1 were given orally 1 h before the induction of the oedema while, in the curative (therapeutic) protocol (right panel), treatment was done 1 h after oedema induction. Data is presented as mean ± s.e.m. (). ***, **, and ** when compared with control. Arrow indicates point of extract administration in the therapeutic protocol.
