Antiallergic and Antiarthritic Effects of Stem Bark Extract of Glyphaea brevis (Spreng) Monachino (Tiliaceae) in Murine Models
Figure 4
Effect of G. brevis extract (GBE) on haloperidol-induced catalepsy. 8–10-week-old ICR mice (20–30 g) received haloperidol 1 mg · kg−1, s.c. and their forepaws placed on a horizontal bar (1 cm in diameter, 10 cm above the table). The duration of catalepsy was measured at 30 min intervals up to 180 min after administration of haloperidol. Drug-vehicle (5 mL kg−1), GBE (30, 100, and 300 mg kg−1), and chlorpheniramine (10 mg kg−1) were given orally for 2 consecutive days ending 30 min before haloperidol injection. Values are mean ± s.e.m. (). Data was subjected to two-way (treatment × time) repetitive measures analysis of variance (ANOVA) with Bonferroni’s post hoc test. Differences were considered significant at , ns is nonsignificant.
