A Validated Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Tenofovir, Emtricitabine, and a Efavirenz and Statistical Approach to Determine the Effect of Variables

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="878295.fig.001a" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Acid hydrolytic degradation </td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="878295.fig.001b" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Base hydrolytic degradation</td></tr></table></td></tr><tr class="fig-image" id="c"><td><img alt="878295.fig.001c" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001c.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(c) </b>Neutral hydrolytic degradation</td></tr></table></td></tr><tr class="fig-image" id="d"><td><img alt="878295.fig.001d" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001d.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(d) </b>Oxidation degradation</td></tr></table></td></tr><tr class="fig-image" id="e"><td><img alt="878295.fig.001e" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001e.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(e) </b>Thermal degradation     </td></tr></table></td></tr><tr class="fig-image" id="f"><td><img alt="878295.fig.001f" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001f.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(f) </b>UV and fluorescent degradation</td></tr></table></td></tr><tr class="fig-image" id="g"><td><img alt="878295.fig.001g" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001g.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(g) </b>Accelerated stability sample</td></tr></table></td></tr><tr class="fig-image" id="h"><td><img alt="878295.fig.001h" src="https://static.hindawi.com/articles/isrn/volume-2013/878295/figures/878295.fig.001h.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(h) </b>Market sample</td></tr></table></td></tr></table>

<table>  HPLC chromatographic separation of TDF, FTC, and EFV and its degradation product in different stress conditions (DP = degradation product, M = emtricitabine, T = tenofovir, F = efavirenz).</table>

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Figure 1: A Validated Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Tenofovir, Emtricitabine, and a Efavirenz and Statistical Approach to Determine the Effect of Variables 

Figure 1 | A Validated Stability-Indicating RP-HPLC Method for the Simultaneous Determination of Tenofovir, Emtricitabine, and a Efavirenz and Statistical Approach to Determine the Effect of Variables 