A Critical Prospect of Structural Designing of Avian Influenza A/H5N1 Neuraminidase Inhibitors That Evade Tamiflu Resistance
Figure 2
Experimentally detected 150-loop (Gly147, Thr148, Val149, Lys150, Asp151, and Arg 152) is denoted by bold near the binding site of H5N1 neuraminidase in complex with oseltamivir—OTV (PDB ID: 2HU0) (a). Experimental proposal of exploiting the 150-cavity of H5N1 NA for the design and development of new inhibitors through modifications of the 4-amino group of OTV in order to make a salt bridge or hydrogen bond with the guanidinium side chain of Arg156 [5], (b).
