A Critical Prospect of Structural Designing of Avian Influenza A/H5N1 Neuraminidase Inhibitors That Evade Tamiflu Resistance
Figure 5
2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), (a). The derivatives of Neu5Ac2en designed by introducing allyl and arylallyl substituents at the C3 position of Neu5Ac2en [34], (b). The compounds were shown to occupy 150-cavity and thus selectively target the pandemic A/H1N1 and avian A/H5N1 viruses [34].
