The Human Frontal Lobes and Frontal Network Systems: An Evolutionary, Clinical, and Treatment Perspective

Table 15

PET brain patterns in dementias.

Dementia subtype	^18 FFDG PET hypometabolism pattern
Alzheimer	Relatively symmetric parietotemporal, medial temporal, posterior cingulate, and frontal association cortex to lesser degree
AD variant (PCAS)	Occipital hypometabolism predominates
FTD behavioral variant	Frontal and anterior temporal hypometabolism
PDD	Temporoparietal, may be similar to AD
DLBD	Occipital and temporal hypometabolism
CVD	Cortical and subcortical, singular or multifocal, correlating with structural imaging abnormality
CBD	Global reduction in metabolism as well as asymmetric prefrontal, premotor, sensorimotor superior temporal, parietal hypometabolism with thalamic hypometabolism contralateral to limb apraxia
Huntington’s	Caudate nucleus hypometabolism and frontal association cortex to a lesser degree
PSP	Caudate nucleus, putamen, thalamus, pons, and superior and anterior frontal cortex

PCAS: posterior cortical atrophy syndrome.
PSP: progressive supranuclear palsy.
FDG PET increases diagnostic accuracy beyond that derived from clinical evaluation. Adapted and modified from [35].