Table of Contents
ISRN Biomathematics
Volume 2013 (2013), Article ID 897658, 53 pages
Review Article

Biochemical Systems Theory: A Review

Department of Biomedical Engineering, Georgia Tech and Emory University, 313 Ferst Drive, Suite 4103, Atlanta, GA 30332-0535, USA

Received 24 September 2012; Accepted 19 October 2012

Academic Editors: R. Pérez-Correa and W. Raffelsberger

Copyright © 2013 Eberhard O. Voit. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools that facilitate the analysis of dynamic biological systems. This paper depicts major developments in BST up to the current state of the art in 2012. It discusses its rationale, describes the typical strategies and methods of designing, diagnosing, analyzing, and utilizing BST models, and reviews areas of application. The paper is intended as a guide for investigators entering the fascinating field of biological systems analysis and as a resource for practitioners and experts.