Table of Contents
ISRN Nephrology
Volume 2013, Article ID 898125, 6 pages
Review Article

The Pleiotropic Effect of Vitamin D

1Division of Nephrology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, No. 707, Section 3, Chung Yang Road, Hualien 97004, Taiwan
2School of Medicine, Tzu Chi University, Hualien, Taiwan
3Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan

Received 17 June 2013; Accepted 5 August 2013

Academic Editors: T. Doi and C. G. Musso

Copyright © 2013 Yu-Hsien Lai and Te-Chao Fang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The novel roles of vitamin D were discovered and valued in this century. In addition to the maintenance of calcium and phosphorus balance, vitamin D regulates the function of the kidneys, heart, and immune system. Moreover, its anti-inflammatory, antiapoptotic, and antifibrotic roles have gained considerable attention. Vitamin D is also important for the maintenance of homeostasis by regulation of hormone secretion, cell proliferation, and differentiation. This paper will review these pleiotropic functions of vitamin D.