Table of Contents
ISRN Dermatology
Volume 2013, Article ID 907189, 4 pages
http://dx.doi.org/10.1155/2013/907189
Research Article

Effect of Infliximab on the UVB-Induced Apoptosis of Keratinocytes Infected by HPV38 E6/E7

1Molecular and Cell Biology Laboratory, Université de Franche Comté, EA3181, SFR FED4234, Besançon, France
2Department of Dermatology, Centre Hospitalier Universitaire, 25030 Besançon, France
3Department of Infections and Cancer Biology, IARC, Lyon, France

Received 7 January 2013; Accepted 26 January 2013

Academic Editors: M. Alaibac, S.-C. Chao, E. Pasmatzi, Y. Tuzun, and J. F. Val Bernal

Copyright © 2013 François Aubin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The question of the effect of anti-TNF-alpha in skin carcinogenesis is especially relevant in view of the increased use of these drugs for the treatment of autoinflammatory immune diseases. Since ultraviolet radiation and human papillomavirus are involved in skin carcinogenesis, we wished to investigate the effect of TNF-alpha antagonists on the UVB-induced apoptosis of keratinocytes infected by HPV38. Our results indicate that anti-TNF agent, infliximab, does not contribute to the survival of HPV38-transduced keratinocytes with UVB-induced DNA damages.