Marked Effects of Tachykinin in Myositis Both in the Experimental Side and Contralaterally: Studies on NK-1 Receptor Expressions in an Animal Model
Figure 2
Immunoreaction patterns for cells in inflammatory infiltrates are shown. Sections are from gastrocnemius muscle specimens, 1-week group ((a), (b), and (e)–(h)), 6-week group (c), exercised sides, and soleus muscle specimen of the 6-week group, nonexercised side (d). In (a)–(d), the presence of cellular NK-1R immunoreactions is seen (arrows). The reactions show frequently a granular appearance. Double staining for SP (e) and NK-1R (f) show that there is partly colocalization (arrows), partly not colocalization (arrowheads). Ordinary staining for NK-1R shows the presence of marked immunoreactions in cells (g) (arrows) (low magnification), whereas there are no specific immunoreactions in a parallel section processed for NK-1R after preabsorption with NK-1R antigen (h). The immunoreactive cells seen in (g) are scattered in the connective tissue and coalesced into a muscle fibre (asterisk (g), c.f. (h)). Arrows in (h) point at nonimmunoreactive cells. Bars = 25 μm.
