Table of Contents
ISRN Oncology
Volume 2013, Article ID 910849, 8 pages
Research Article

Chromosome Aberrations in Cells Infected with Bovine Papillomavirus: Comparing Cutaneous Papilloma, Esophagus Papilloma, and Urinary Bladder Lesion Cells

1Laboratório de Genética, Instituto Butantan, Avenida Vital Brasil, 1500, Butantã, 05503-900 São Paulo, SP, Brazil
2Programa de Pós-graduação em Biologia Estrutural e Funcional, Universidade Federal de São Paulo, Rua Botucatu, 740, 04023-900 São Paulo, SP, Brazil
3Programa de Pós-graduação Interunidades em Biotecnologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Avenida Prof. Lineu Prestes, 2415 Edifício ICB-III-Cidade Universitária, 05508-900 São Paulo, SP, Brazil
4Department of Biology, Naples University Federico II, Via Mezzocannone 16, 80134 Naples, Italy
5Departamento de Biologia, Universidade Federal da Integração Latino-Americana (UNILA), Avenida Tancredo Neves, 6731 bloco 4, 85867-970 Foz do Iguaçú, PR, Brazil

Received 3 June 2013; Accepted 2 July 2013

Academic Editors: K. Sonoda, M. Stracke, and K. van Golen

Copyright © 2013 S. R. C. Campos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The majority of malignant cells present genetic instability with chromosome number changes plus segmental defects: these changes involve intact chromosomes and breakage-induced alterations. Some pathways of chromosomal instability have been proposed as random breakage, telomere fusion, and centromere fission. Chromosome alterations in tumor cells have been described in animal models and in vitro experiments. One important question is about possible discrepancies between animal models, in vitro studies, and the real events in cancer cells in vivo. Papillomaviruses are relevant agents in oncogenic processes related to action on host genome. Recently, many reports have discussed the presence of virus DNA in peripheral blood, in humans and in animals infected by papillomaviruses. The meaning of this event is of controversy: possible product of apoptosis occurring in cancer cells, metastasized cancer cells, or active DNA sequences circulating in bloodstream. This study compares chromosome aberrations detected in bovine cells, in peripheral blood cells, and in BPV lesion cells: the literature is poor in this type of study. Comparing chromosome aberrations described in the different cells, a common mechanism in their origin, can be suggested. Furthermore blood cells can be evaluated as an effective way of virus transmission.