Challenges in Enzymatic Route of Mannitol Production

Table 1

LAB used for mannitol production with their yield and their carbon source.

Lactic acid bacteria	Carbon source	Fermentation condition	Yield/Productivity	References
Leuconostoc pseudomesenteroides	Fructose	pH 4.5	6.3 g/L/h; 94 mol%	[2]
ATCC 12291; Leuc. pseudomesenteroides (immobilized)	Fructose	pH 4.5; Temp 20°C	1 g/L/h; 85 mol%	[2]
Leuc. pseudomesenteroides	On hydrolyzed starch (fructose and glucose)	Batch culture	3.8 g/L/h; 92 mol%	[2]
Leuc. pseudomesenteroides	(Fructose and glucose)	Fed-batch culture	6.3 g/L/h; 85 mol%	[2]
Leuc. pseudomesenteroides (mutant) immobilized on polyurethane foam	Hydrolyzed starch	Fed-batch culture	7.7 g/L/h; 85 mol%	[2]
Leuc. pseudomesenteroides (mutant) immobilized on polyurethane foam	Hydrolyzed starch	Continuous mode	8.9 g/L/h
Oenococcus oeni	Glucose and fructose	Batch culture normal temp Ph	0.2 g/L/h; 83 mol%	[13]
Lactobacillus sp. (L.)	Fructose	Flask culture	0.72 mol/mol fructose; <1 g/L/h; 86 mol%	[14]
Leuconostoc mesenteroides	Fructose	Flask culture	>80%	[15]
L. sanfranciscensis	Fructose; glucose	Fed-batch	0.5 g/L/h	[16]
Leuc. pseudomesenteroides; ATCC 12291 (immobilized cell)	Fructose; glucose	Batch	30 g/L/h; 85 mol%	[17]
Lactococcus lactis strain F17851 (nongrowing)	Glucose	Batch	90 mM	[18]
F110089 ldh mutant	Glucose	Batch	5.5 g/L/h	[19]
F19630 double mutant	Glucose	Batch	5.7 g/L/h	[19]
Nongrowing MG1363	Glucose	Batch	18.3 g/L/h	[20]
Non growing MG1363	Glucose	Batch	32.8 mol of product/mol of glucose	[19]
L. intermedius NRRL B-3693	Fructose	pH 5.0; temp 37°C	64% w/w; 4 g/L/h	[21]
L. intermedius NRRL B-3693	Fructose	Fed batch	95% w/w; 5.9 g/L/h	[21]
L. intermedius NRRL B-3693	Fructose	Continuous recycle	40 g/L/h	[21]
L. intermedius NRRL B-3693	Molasses and fructose syrup (1 : 1) fructose glucose (4 : 1)	Media design using soy peptone (5 g/L) corn steep liquor (50 g/L)	69% w/w; 4.7 g/L/h	[6]