Table of Contents
ISRN Biomedical Engineering
Volume 2013 (2013), Article ID 919802, 9 pages
http://dx.doi.org/10.1155/2013/919802
Research Article

Diffusion in Replica Healthy and Emphysematous Alveolar Models Using Computational Fluid Dynamics

Department of Mechanical Engineering, Kate Gleason College of Engineering, Rochester Institute of Technology, 76 Lomb Memorial Drive, Building 9, Rochester, NY 14623, USA

Received 11 March 2013; Accepted 8 May 2013

Academic Editors: A. Qiao and C. Thielemann

Copyright © 2013 Edward M. Harding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. F. Adams, P. M. Barnes, and J. L. Vickerie, “Summary Health Statistics for the U.S. Population: National Health Interview Survey, 2007,” Vital and Health Statistics, vol. 10, no. 238, pp. 1–104, 2008. View at Google Scholar
  2. A. S. Buist, M. A. McBurnie, W. M. Vollmer et al., “International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study,” The Lancet, vol. 370, no. 9589, pp. 741–750, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. Ncrp, “Deposition, retention and dosimetry of inhaled radioactive substances,” Ncrp Report 125, Bethesda, MD, USA, 1997. View at Google Scholar
  4. S. Anjilvel and B. Asgharian, “A multiple-path model of particle deposition in the rat lung,” Fundamental and Applied Toxicology, vol. 28, no. 1, pp. 41–50, 1995. View at Publisher · View at Google Scholar · View at Scopus
  5. C. P. Yu and C. K. Diu, “Total and regional deposition of inhaled aerosols in humans,” Journal of Aerosol Science, vol. 14, no. 5, pp. 599–609, 1983. View at Publisher · View at Google Scholar · View at Scopus
  6. D. B. Ingham, “Diffusion of aerosols from a stream flowing through a cylindrical tube,” Journal of Aerosol Science, vol. 6, no. 2, pp. 125–132, 1975. View at Google Scholar · View at Scopus
  7. D. B. Ingham, “Diffusion of aerosols from a stream flowing through a short cylindrical pipe,” Journal of Aerosol Science, vol. 15, no. 5, pp. 637–641, 1984. View at Google Scholar · View at Scopus
  8. D. B. Ingham, “Diffusion of aerosols in the entrance region of a smooth cylindrical pipe,” Journal of Aerosol Science, vol. 22, no. 3, pp. 253–257, 1991. View at Google Scholar · View at Scopus
  9. H. Kumar, M. H. Tawhai, E. A. Hoffman, and C. Lin, “The effects of geometry on airflow in the acinar region of the human lung,” Journal of Biomechanics, vol. 42, no. 11, pp. 1635–1642, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Sznitman, T. Heimsch, J. H. Wildhaber, A. Tsuda, and T. Rösgen, “Respiratory flow phenomena and gravitational deposition in a three-dimensional space-filling model of the pulmonary acinar tree,” Journal of Biomechanical Engineering, vol. 131, no. 3, pp. 031010-1–031010-16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. E. J. Berg, J. L. Weisman, M. J. Oldham, and R. J. Robinson, “Flow field analysis in a compliant acinus replica model using particle image velocimetry (PIV),” Journal of Biomechanics, vol. 43, no. 6, pp. 1039–1047, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Sturm and W. Hofmann, “Stochastic simulation of alveolar particle deposition in lungs affected by different types of emphysema,” Journal of Aerosol Medicine, vol. 17, no. 4, pp. 357–372, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Tsuda, F. S. Henry, and J. P. Butler, “Chaotic mixing of alveolated duct flow in rhythmically expanding pulmonary acinus,” Journal of Applied Physiology, vol. 79, no. 3, pp. 1055–1063, 1995. View at Google Scholar · View at Scopus
  14. C. Darquenne, “A realistic two-dimensional model of aerosol transport and deposition in the alveolar zone of the human lung,” Journal of Aerosol Science, vol. 32, no. 10, pp. 1161–1174, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Haber, D. Yitzhak, and A. Tsuda, “Gravitational deposition in a rhythmically expanding and contracting alveolus,” Journal of Applied Physiology, vol. 95, no. 2, pp. 657–671, 2003. View at Google Scholar · View at Scopus
  16. J. Sznitman, F. Heimsch, T. Heimsch, D. Rusch, and T. Rösgen, “Three-dimensional convective alveolar flow induced by rhythmic breathing motion of the pulmonary acinus,” Journal of Biomechanical Engineering, vol. 129, no. 5, pp. 658–665, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. E. M. Harding Jr. and R. J. Robinson, “Flow in a terminal alveolar sac model with expanding walls using computational fluid dynamics,” Inhalation Toxicology, vol. 22, no. 8, pp. 669–678, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Karl, F. S. Henry, and A. Tsuda, “Low Reynolds number viscous flow in an alveolated duct,” Journal of Biomechanical Engineering, vol. 126, no. 4, pp. 420–429, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. J. M. Oakes, S. Day, S. J. Weinstein, and R. J. Robinson, “Flow field analysis in expanding healthy and emphysematous alveolar models using particle image velocimetry,” Journal of Biomechanical Engineering, vol. 132, no. 2, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. E. J. Berg and R. J. Robinson, “Stereoscopic particle image velocimetry analysis of healthy and emphysemic alveolar sac models,” Journal of Biomechanical Engineering, vol. 133, no. 6, Article ID 061004, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Lippmann and R. E. Albert, “The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract,” American Industrial Hygiene Association journal, vol. 30, no. 3, pp. 257–275, 1969. View at Google Scholar · View at Scopus
  22. D. Pavia, M. L. Thomson, S. W. Clarke, and H. S. Shannon, “Effect of lung function and mode of inhalation on penetration of aerosol into the human lung,” Thorax, vol. 32, no. 2, pp. 194–197, 1977. View at Google Scholar · View at Scopus
  23. T. L. Chan and M. Lippmann, “Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans,” American Industrial Hygiene Association Journal, vol. 41, no. 6, pp. 399–409, 1980. View at Google Scholar · View at Scopus
  24. W. Stahlhofen, J. Gebhart, and J. Heyder, “Experimental determination of the regional deposition of aerosol particles in the human respiratory tract,” American Industrial Hygiene Association Journal, vol. 41, no. 6, pp. 385–398, 1980. View at Google Scholar · View at Scopus
  25. W. Stahlhofen, J. Gebhart, and J. Heyder, “Biological variability of regional deposition of aerosol particles in the human respiratory tract,” American Industrial Hygiene Association Journal, vol. 42, no. 5, pp. 348–352, 1981. View at Google Scholar · View at Scopus
  26. P. C. Emmett, R. J. Aitken, and W. J. Hannan, “Measurements of the total and regional deposition of inhaled particles in the human respiratory tract,” Journal of Aerosol Science, vol. 13, no. 6, pp. 549–560, 1982. View at Google Scholar · View at Scopus
  27. C. S. Kim and P. A. Jaques, “Respiratory dose of inhaled ultrafine particles in healthy adults,” Philosophical Transactions of the Royal Society A, vol. 358, no. 1775, pp. 2693–2705, 2000. View at Google Scholar · View at Scopus
  28. M. Kohlhäufl, P. Brand, T. Meyer et al., “Detection of impaired intrapulmonary convective mixing by aerosol bolus dispersion in patients with emphysema,” European Journal of Medical Research, vol. 2, no. 3, pp. 121–128, 1997. View at Google Scholar · View at Scopus
  29. P. Brand, C. Rieger, H. Schulz, T. Beinert, and J. Heyder, “Aerosol bolus dispersion in healthy subjects,” European Respiratory Journal, vol. 10, no. 2, pp. 460–467, 1997. View at Publisher · View at Google Scholar · View at Scopus
  30. R. F. Phalen, H. Yeh, O. G. Raabe, and D. J. Velasquez, “Casting the lungs in situ,” Anatomical Record, vol. 177, no. 2, pp. 255–264, 1973. View at Google Scholar · View at Scopus
  31. M. Kohlhäufl, P. Brand, G. Scheuch et al., “Aerosol morphometry and aerosol bolus dispersion in patients with CT-determined combined pulmonary emphysema and lung fibrosis,” Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung, vol. 13, no. 2, pp. 117–124, 2000. View at Google Scholar · View at Scopus
  32. B. Haefeli-Bleuer and E. R. Weibel, “Morphometry of the human pulmonary acinus,” Anatomical Record, vol. 220, no. 4, pp. 401–414, 1988. View at Google Scholar · View at Scopus
  33. M. Kohlhäufl, P. Brand, T. Selzer et al., “Diagnosis of emphysema in patients with chronic bronchitis: a new approach,” European Respiratory Journal, vol. 12, no. 4, pp. 793–798, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. E. R. Weibel, “Lung Structure,” Medicina Thoracalis, vol. 22, no. 5, p. 548, 1965. View at Google Scholar
  35. G. Chen, Solution of Diffusion Equation in Axisymmetrical Coordinates, Master of Science Ohio University, 1994.
  36. W. C. Hinds, Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles, John Wiley & Sons, 1999.
  37. B. Gebhart, Heat Conduction and Mass Transfer, McGraw-Hill, New York, NY, USA, 1993.
  38. T. Chimera, Fine Particle Model (Fpm) for Fluent, Evan Whitby, 2005.
  39. E. G. Damon, B. V. Mokler, and R. K. Jones, “Influence of elastase-induced emphysema and the inhalation of an irritant aerosol on deposition and retention of an inhaled insoluble aerosol in Fischer-344 rats,” Toxicology and Applied Pharmacology, vol. 67, no. 3, pp. 322–330, 1983. View at Google Scholar · View at Scopus
  40. D. L. Lundgren, E. G. Damon, J. H. Diel, and F. F. Hahn, “The deposition, distribution and retention of inhaled 239PuO2 in the lungs of rats with pulmonary emphysema,” Health Physics, vol. 40, no. 2, pp. 231–235, 1981. View at Google Scholar · View at Scopus
  41. J. C. Martin, H. Daniel, and L. Le Bouffant, “Experimental study of pulmonary emphysema in rats exposed to coal dust and papain: effects on the infrastructure and the cell dynamics,” American Industrial Hygiene Association Journal, vol. 41, no. 1, pp. 12–19, 1980. View at Google Scholar · View at Scopus
  42. F. F. Hahn and C. H. Hobbs, “The effect of enzyme-induced pulmonary emphysema in Syrian hamsters on the deposition and long-term retention of inhaled particles,” Archives of Environmental Health, vol. 34, no. 4, pp. 203–211, 1979. View at Google Scholar · View at Scopus
  43. J. L. Mauderly, D. E. Bice, Y. S. Cheng et al., “Influence of preexisting pulmonary emphysema on susceptibility of rats to inhaled diesel exhaust,” American Review of Respiratory Disease, vol. 141, no. 5 I, pp. 1333–1341, 1990. View at Google Scholar · View at Scopus