Critical Analysis of Strand-Biased Somatic Mutation Signatures in TP53 versus Ig Genes, in Genome-Wide Data and the Etiology of Cancer
Table 7
Hotspots in breast cancers for G-site mutations in TP53 in relation to codon, target motif, and likely dC-to-dU deaminase.
Codona
aNumber mutations
bMotif on
cLikely C>U
G>A
G>T
G>C
NTS
TS
DNA deaminase
156
1
0
10
CGC
GCG
AID
157
0
8
0
CGT
ACG
AID
158
2
1
2
CGC
GCG
AID
173
7
8
3
TGT
ACA
AID
175
128
2
1
CGC
GCG
AID
176
6
10
1
TGC
GCA
AID
181
3
1
2
CGC
GCG
AID
196
2
0
5
CGA
TCG
APOBEC1?
216
12
3
0
TGT
ACA
AID
237
17
7
3
TGT
ACA
AID
238
13
6
1
TGT
ACA
AID
242
7
6
1
TGC
GCA
AID
243
5
1
2
TGG
CCA
APOBEC3G?
244
10
0
1
GGG
CGC
APOBEC3G?
244
8
2
0
GGC
GCC
AID
245
38
3
1
CGG
CCG
APOBEC3G
245
14
3
1
GGC
GCC
AID
248
104
7
2
CGG
CGG
APOBEC3G
249
4
1
0
AGG
CCT
APOBEC3G?
249
1
14
2
GGC
GCC
AID
258
3
1
1
GGA
TCC
APOBEC1?
266
2
2
3
GGG
CCC
APOBEC3G?
266
10
4
0
GGA
TCC
APOBEC1
272
10
1
0
GGT
ACC
AID
273
93
5
5
CGT
ACG
AID
275
8
7
0
TGT
ACA
AID
277
2
4
0
TGT
ACA
AID
280
7
1
14
AGA
TCT
APOBEC1?
281
5
0
6
AGA
TCT
APOBEC1?
282
1
3
3
CGG
CCG
APOBEC3G
283
3
0
3
CGC
GCG
AID
285
21
1
0
AGA
TCT
APOBEC1?
286
9
0
0
GGA
TCC
APOBEC1?
294
0
5
0
GGA
TCC
APOBEC1?
aOnly G sites with ≥5 mutations listed.
bNTS: nontranscribed strand; TS: transcribed strand.
cFrom Beale et al. 2004 [21, Table 2]. ?indicates that first two bases in TS motif consistent with deamination target in [21].
