Table of Contents
ISRN Physiology
Volume 2013, Article ID 921527, 12 pages
http://dx.doi.org/10.1155/2013/921527
Research Article

Differences in Expression and Function in the Atrium versus Ventricle of the Sodium-Calcium Exchanger in the Embryonic Chicken Heart

1Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65211, USA
2Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
3Department of Biological Engineering, University of Missouri, Columbia, MO 65211, USA

Received 17 May 2013; Accepted 1 August 2013

Academic Editors: A. W. Midgley and F. Moccia

Copyright © 2013 Luis Polo-Parada and Amol A. Modgi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Heart function is well known to be dependent on intrinsic electrical activity. This electrical activity is primarily mediated by a combination of interactions among various ionic channels and transporters. In this study, we demonstrate that the Na+-Ca2+ exchanger (NCX) is equally present in both atrial and ventricular cells at early stages of development (st. 13). However, ventricular cells exhibit an increase in NCX messenger ribonucleic acid (mRNA) levels during later stages of development, while levels in atrial cells remain constant. We demonstrate that the current density of the NCX increases with development in the ventricle but remains constant in the atrial cells. Furthermore we demonstrate that the NCX has a major role in shaping the cardiac action potential at early stages mainly in ventricular cells (st. 14) than later mainly in the atrial cells (st. 30).