Gene Expression Profile Analysis of T1 and T2 Breast Cancer Reveals Different Activation Pathways

Table 3

Downregulated pathways in T1 breast cancer tumors compared to T2 tumors.

Term	Genes	Count	%	𝑃 value	Benjamini
Neurotrophin signaling pathway (KEGG_PATHWAY)	YWHAZ, GRB2, RAC1, YWHAQ, FRS2	5	2.8	4.2𝐸−2	9.8𝐸−1
p38 MAPK Signaling Pathway (BIOCARTA)	GRB2, RAC1, MKNK1	3	1.7	5.0𝐸−2	9.8𝐸−1
Prion diseases (KEGG_PATHWAY)	C1QA, C1QB, C1QC	3	1.7	5.3𝐸−2	9.1𝐸−1
Jak-STAT signaling pathway (KEGG_PATHWAY)	OSM, IFNA2, GRB2, IL10RA, IL4R	5	2.8	8.1𝐸−2	9.2𝐸−1
Systemic lupus erythematosus (KEGG_PATHWAY)	C1QA, C1QB, HLA-DPB1, C1QC	4	2.2	8.7𝐸−2	8.7𝐸−1
Toll-like receptor signaling pathway (KEGG_PATHWAY)	IFNA2, MYD88, TICAM1, RAC1	4	2.2	9.1𝐸−2	8.2𝐸−1