Table of Contents
ISRN Dermatology
Volume 2013 (2013), Article ID 930164, 11 pages
Review Article

Skin Photoaging and the Role of Antioxidants in Its Prevention

1Faculty of Health Studies, University of Ljubljana, Zdravstvena pot 5, 1000 Ljubljana, Slovenia
2Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
3Department of Dermatology, Cambridge University Hospitals, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK

Received 9 July 2013; Accepted 7 August 2013

Academic Editors: E. Alpsoy, C.-C. Lan, and J. F. Val-Bernal

Copyright © 2013 Ruža Pandel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Photoaging of the skin depends primarily on the degree of ultraviolet radiation (UVR) and on an amount of melanin in the skin (skin phototype). In addition to direct or indirect DNA damage, UVR activates cell surface receptors of keratinocytes and fibroblasts in the skin, which leads to a breakdown of collagen in the extracellular matrix and a shutdown of new collagen synthesis. It is hypothesized that dermal collagen breakdown is followed by imperfect repair that yields a deficit in the structural integrity of the skin, formation of a solar scar, and ultimately clinically visible skin atrophy and wrinkles. Many studies confirmed that acute exposure of human skin to UVR leads to oxidation of cellular biomolecules that could be prevented by prior antioxidant treatment and to depletion of endogenous antioxidants. Skin has a network of all major endogenous enzymatic and nonenzymatic protective antioxidants, but their role in protecting cells against oxidative damage generated by UV radiation has not been elucidated. It seems that skin’s antioxidative defence is also influenced by vitamins and nutritive factors and that combination of different antioxidants simultaneously provides synergistic effect.