International Scholarly Research Notices / 2013 / Article / Tab 3

Review Article

Skin Photoaging and the Role of Antioxidants in Its Prevention

Table 3

Exogenous antioxidants with no protective/beneficial effects.

AntioxidantOutcome of the study (nonbeneficial results)Study

LycopeneLycopene enhances UVA-induced oxidative stress in C3H cellsYeh et al., 2005 [95]
CarotenoidsCarotenoids were not protective against DNA lesions repairable by excision repairWolf et al., 1988 [96]
No significant change in the intensity of erythema; no effects of supplementationGarmyn et al., 1995 [97]
No significant difference between the beta-carotene and placebo groups in incidence of cancerGreen et al., 1999 [98]
No significant effect of -carotene on either number or time of occurrence of new nonmelanoma skin cancerGreenberg et al., 1990 [99]
An average of 12 years of supplementation with beta-carotene does not affect the development of a first NMSC Frieling et al., 2000 [100]
Supplementation with -carotene produced no reduction of the incidence of malignant neoplasmsHennekens et al., 1996 [101]

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