Research Article
Differential Prognostic Indicators for Locoregional Recurrence, Distant Recurrence, and Death of Breast Cancer
Table 1
Clinical profiles and treatment of breast cancer (
), by first occurring events.
| Characteristics | | | Recurrence | | | value | Event-free () |
Locoregional () | Distant () | Death () | | % | | % | | % | | % |
| Age (year) | | | | | | | | | | ≤45 | 166 | 26.1 | 25 | 30.1 | 30 | 38.5 | 4 | 12.9 | 0.030 | >45 | 471 | 73.9 | 58 | 69.9 | 48 | 61.5 | 27 | 87.1 | | Types of surgery | | | | | | | | | | MRM | 543 | 85.2 | 72 | 86.8 | 70 | 89.7 | 26 | 83.9 | 0.120 | Simple mastectomy | 40 | 6.3 | 9 | 10.8 | 5 | 6.4 | 4 | 12.9 | | BCS | 54 | 8.5 | 2 | 2.4 | 3 | 3.9 | 1 | 3.2 | | Pathological tumor size (cm) | | | | | | | | | | ≤2 | 272 | 42.7 | 23 | 27.7 | 16 | 20.5 | 10 | 32.3 | <0.001 | >2 | 365 | 57.3 | 60 | 72.3 | 62 | 79.5 | 21 | 67.7 | | Histological type | | | | | | | | | | Ductal carcinoma | 590 | 92.6 | 82 | 98.8 | 77 | 98.7 | 30 | 96.8 | 0.191 | Lobular carcinoma | 5 | 0.8 | 0 | 0.00 | 0 | 0.00 | 0 | 0.00 | | Other types | 42 | 6.6 | 1 | 1.2 | 1 | 1.3 | 1 | 3.2 | | Histological grade | | | | | | | | | | I | 110 | 19.2 | 8 | 9.9 | 9 | 12.0 | 2 | 7.4 | 0.027 | II | 280 | 48.9 | 46 | 56.8 | 38 | 50.7 | 9 | 33.3 | | III | 183 | 31.9 | 27 | 33.3 | 28 | 37.3 | 16 | 59.3 | | Stage | | | | | | | | | | 1 | 218 | 34.2 | 16 | 19.3 | 9 | 11.5 | 3 | 9.7 | <0.001 | 2 | 353 | 55.4 | 43 | 51.8 | 41 | 52.6 | 22 | 71.0 | | 3 | 66 | 10.4 | 24 | 28.9 | 28 | 35.9 | 6 | 19.3 | | Dissected axillary lymph nodes | | | | | | | | | | <10 | 125 | 20.3 | 20 | 25.6 | 17 | 23.0 | 7 | 24.1 | 0.641 | ≥10 | 490 | 79.7 | 58 | 74.4 | 57 | 77.0 | 22 | 75.9 | | Positive axillary lymph nodes | | | | | | | | | | ≤3 | 530 | 86.0 | 42 | 53.9 | 38 | 51.4 | 20 | 69.0 | <0.001 | >3 | 86 | 14.0 | 36 | 46.1 | 36 | 48.6 | 9 | 31.0 | | LVI | | | | | | | | | | Absent | 377 | 60.1 | 23 | 29.5 | 22 | 29.0 | 11 | 36.7 | <0.001 | Present | 250 | 39.9 | 55 | 70.5 | 54 | 71.0 | 19 | 63.3 | | Receptor status | | | | | | | | | | ER receptor | | | | | | | | | | Positive | 398 | 63.6 | 44 | 55.0 | 36 | 47.4 | 20 | 66.7 | 0.027 | Negative | 228 | 36.4 | 36 | 45.0 | 40 | 52.6 | 10 | 33.3 | | PR receptor | | | | | | | | | | Positive | 351 | 56.0 | 42 | 52.5 | 30 | 39.5 | 18 | 60.0 | 0.047 | Negative | 276 | 44.0 | 38 | 47.5 | 46 | 60.5 | 12 | 40.0 | | HER2 receptor | | | | | | | | | | Positive | 236 | 40.5 | 38 | 54.3 | 35 | 49.3 | 11 | 39.3 | 0.093 | Negative | 347 | 59.5 | 32 | 45.7 | 36 | 50.7 | 17 | 60.7 | | Treatment | | | | | | | | | | Radiotherapy | | | | | | | | | | Yes | 199 | 31.3 | 41 | 49.4 | 52 | 66.7 | 8 | 26.7 | <0.001 | No | 436 | 68.7 | 42 | 50.6 | 26 | 33.3 | 22 | 73.3 | | Hormonal therapy | | | | | | | | | | Yes | 418 | 65.6 | 48 | 57.8 | 38 | 48.7 | 23 | 74.2 | 0.011 | No | 219 | 34.4 | 35 | 42.2 | 40 | 51.3 | 8 | 25.8 | | Chemotherapy | | | | | | | | | | Yes | 547 | 86.3 | 80 | 96.4 | 73 | 93.6 | 19 | 63.3 | <0.001 | No | 87 | 13.7 | 3 | 3.6 | 5 | 6.4 | 11 | 36.7 | |
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MRM: modified radical mastectomy; BCS: breast-conserving surgery; LVI: lymphovascular invasion; ER: estrogen receptor; PR: progesterone receptor; HER2: human epidermal growth factor receptor 2.
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