Translational Research in Stem Cell Treatment of Neuromuscular Diseases

Table 1

Table summarizing the preclinical studies on the treatment of ALS with stem cells.

Stem cell	Animal model	Result	References
Mouse BMCs	SOD1^G93A mouse	No effect	[48]
Mouse BMCs	SOD1^G93A mouse	Prolonged life span and functional improvement	[49]
Mouse BMCs	SOD1^G93A mouse	Prolonged life span and delayed disease onset	[50]
Mouse BMCs	SOD1^G93A mouse	Functional improvement	[51]
Rat BMCs	SOD1^Leu126delTT mouse	Prolonged life span in female mice only	[52]
Rat BMCs	hSOD1(G93A) rat	Prolonged life span, decreased motor neuron loss, and preserved motor functions	[53]
Rat BMCs	SOD1^G93A rat	Prolonged life span and functional improvement	[54]
Human BMCs	SOD1^G93A mouse	Prolonged life span and delayed disease onset	[55]
Human BMCs	SOD1^G93A mouse	Prolonged life span functional improvement, and delayed disease onset	[56]
Human BMCs or; Human BMC-derived NSCs	SOD1^G93A mouse	No effect	[57]
Human BMCs	SOD1^G93A mouse	Functional improvement	[58]
Human BMCs	SOD1^G93A rat	Prolonged life span and functional improvement	[59]
Human UCBCs	SOD1^G93A mouse	Prolonged life span	[60]
Human UCBCs	SOD1^G93A mouse	Prolonged life span	[61]
Human UCBCs	SOD1^G93A mouse	Prolonged life span and functional improvement	[62]
Human UCBCs	SOD1^G93A mouse	Prolonged life span, functional improvement, delayed disease onset, and histological improvement	[63]
Human UCBCs	SOD1^G93A mouse	No effect	[64]
Human UCBCs or; Human UCBC-derived NSCs	SOD1^G93A mouse	No effect	[57]
Human UCBCs	SOD1^G93A mouse	Prolonged life span and amelioration of the symptoms	[65]
Human UCBCs	SOD1^G93A mouse	Not mentioned	[66]
Human NPC	SOD1^G93A rat	No effect	[67]
Human NPC	SOD1^G93A rat	No effect	[68]
Human NSCs	SOD1^G93A rat	Prolonged life span, functional improvement, and delayed disease onset	[69]
Human NSCs	SOD1^G93A rat	Prolonged life span and functional improvement	[70]
Human NSCs	SOD1^G93A mouse	Prolonged life span and delayed disease onset	[71]
Human NSCs	SOD1^G93A rat	Prolonged life span	[69]
Human NSCs	SOD1^G93A mouse	Improved neuromuscular transmission	[72]
Mouse NSCs	SOD1^G93A mouse	Prolonged life span and delayed disease onset	[73]
Rat NSCs	SOD1^G93A rat	Not mentioned	[74]
Mouse OB-NPCs	SOD1^G93A mouse	Prolonged life span, functional improvement, and delayed disease onset	[75]
Mouse ESCs	SOD1^G93A rat	No effect	[76]
Human GRPs	SOD1^G93A mouse	Not mentioned	[77]