Antiurolithiatic Activity of Extract and Oleanolic Acid Isolated from the Roots of Lantana camara on Zinc Disc Implantation Induced Urolithiasis
Table 1
Effect of oleanolic acid and ELC on zinc implantation model.
Serial number
Groups
Urine output (mL)
Urinary calcium output (mg/dL)
Weight of calculi (mg)
Control
2.6 ± 0.2
—
—
Sham Control
2.1 ± 0.2
10 ± 3.1**
—
Disc Implanted
1.6 ± 0.1*
23 ± 2.7
111 ± 8.6
Cystone 500 mg/kg
2.6 ± 0.3
12 ± 2.7**
6.7 ± 2.9***
OA 60 mg/kg
1.9 ± 0.1
12 ± 0.7**
11 ± 2.4***
OA 80 mg/kg
2 ± 0.2
10 ± 2**
11 ± 1.9***
OA 100 mg/kg
2.7 ± 0.3
8.4 ± 1.8**
4.1 ± 1.3***
ELC 200 mg/kg
2.4 ± 05
11 ± 1.2***
13 ± 1.7***
Value represents; mean ± SEM. Statistical analysis was performed by Dunnett’s multiple comparison test. *, as compared with naive control, **, and *** as compared with disc implanted group.
