Table of Contents
ISRN Genetics
Volume 2013, Article ID 952518, 8 pages
http://dx.doi.org/10.5402/2013/952518
Review Article

Study Designs in Genetic Epidemiology

1Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Iran
2Tabriz Health Services Management Research Centre, Department of Community and Family Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz 5166615739, Iran
3Tabriz University of Medical Sciences, Iran
4Department of Plant Breeding and Biotechnology, School of Agriculture, University of Tabriz, Iran

Received 16 March 2013; Accepted 15 April 2013

Academic Editors: M. M. DeAngelis, J. Moreaux, and X.-X. Zhang

Copyright © 2013 Leyla Sahebi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Genetic epidemiology, as a relatively new issue, aims to explore the independent role of genetic-environmental determinants of diseases. Genetic epidemiology studies, depending on the objective, encompass the most preliminary surveys from the attempts to find family history in the occurrence of diseases to the most advanced surveys including specific strategies by clinical trials in the prevention of genetic diseases. Different objectives in genetic epidemiology studies require special methods and study designs. In this review, chief designs including familial aggregation, heritability, segregation, linkage, and association are evaluated; likewise, the purpose of diverse kinds of studies and analyses is briefly discussed. The utilization of study designs and related analyses according to the aims are the main issues and necessary in the accurate implementation of the study. Some methodological issues in relation to studies on tuberculosis are also reported. Attention to these issues might be useful in the implementation of these methods in the studies designed for the prevention and treatment of genetic disorders.