Research Article
Association of Leukotriene Gene Variants and Plasma LTB4 Levels with Coronary Artery Disease in Asian Indians
Table 1
Final list of functional SNPs (
= 14) selected for genotyping based on the predicted functional effect and estimated risk score.
| | Gene | rs ID | Position (bp) | Type of SNP | Fast SNP rank | Literature Tagging SNP |
| | ALOX5 | rs2291427 | 45256230 | intronic | (1-2) | | | rs12762303 | 45189177 | 5′ upstream | (1–3) | | | rs1864414 | 45190567 | Intronic | (1-2) | | | rs41314980 | 45261505 | 3′ UTR | (0-0) | |
| | ALOX5AP | rs4769055 | 30207830 | intronic | (1-2) | rs10507391 (Hap A/B) | | rs17222919 | 30206329 | 5′ upstream | (0-0) | | | rs4360791 | 30216020 | intronic | (0-0) | rs9551963 (Hap A) | | rs3803277 | 30216308 | intronic | (0-0) | rs9551963 (Hap A) | | rs1132340 | 30236462 | 3′ UTR | (0-0) | rs4769874 (Hap A) |
| | LTA4H | rs2660899 | 94954551 | 5′upstream | (1–3) | | | rs17525495 | 94953508 | 5′ upstream | (0-0) | | | rs2660898 | 94950128 | intronic | (1-2) | Hap K | | rs1978331 | 94933332 | intronic | (1-2) | Hap K, rs2540482, rs2660845 |
| | LTC4S | rs730012 | 179153244 | 5′ upstream | (0-0) | |
|
|
1-2: very low to low; 1–3: very low to medium; 0: unknown.
|
