Table of Contents
ISRN Physiology
Volume 2013, Article ID 986320, 13 pages
Review Article

Signalling in Neutrophils: A Retro Look

Department of Microbiology-Infectiology and Immunology, Faculty of Medicine, Laval University, Centre de Recherche du CHU de Québec, 2705 Boulevard Laurier, Room T 1-42, Québec, QC, Canada G1V 4G2

Received 18 August 2013; Accepted 17 September 2013

Academic Editors: D. Lominadze, F. Moccia, and M. J. Tuvim

Copyright © 2013 Paul H. Naccache. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This review presents a summary of signalling events related to the activation of human polymorphonuclear neutrophils by a variety of soluble and particulate agonists. It is not intended as a comprehensive review of this vast field or as a presentation of the multiple new aspects of neutrophil functions that are being documented at an ever faster rate. Its aim is rather to focus on multiple aspects of major signalling pathways that, in the view of this reviewer, are currently shadowed by present trends and to provide the core evidence for their implication and the limitations of our present knowledge. More specifically, this review starts with cell surface receptors and some of their functional and biological properties and then moves on to downstream transducers (G proteins) and effectors (the phosphoinositide, tyrosine kinases, and cyclic nucleotide pathways). Classical second messengers (calcium, protein kinase C, polyphosphoinositides, and cyclic nucleotides) are emphasized. It is hoped that this presentation will not only remind present-day investigators of the central role these pathways play in the regulation of the functional responsiveness of neutrophils, but that it will also highlight some of the areas deserving additional investigation.