International Scholarly Research Notices

International Scholarly Research Notices / 2014 / Article

Clinical Study | Open Access

Volume 2014 |Article ID 105492 |

Rajandeep Singh Bali, Sushant Verma, P. N. Agarwal, Rajdeep Singh, Nikhil Talwar, "Perforation Peritonitis and the Developing World", International Scholarly Research Notices, vol. 2014, Article ID 105492, 4 pages, 2014.

Perforation Peritonitis and the Developing World

Academic Editor: M. Chiarugi
Received15 Jan 2014
Accepted16 Mar 2014
Published02 Apr 2014


Background. Perforation peritonitis is the one of the commonest emergency encountered by surgeons. The aim of this paper is to provide an overview of the spectrum of perforation peritonitis managed in a single unit of a tertiary care hospital in Delhi. Methods. A retrospective study was carried out between May 2010 and June 2013 in a single unit of the department of Surgery, Lok Nayak Hospital, Delhi. It included 400 patients of perforation peritonitis (diffuse or localized) who were studied retrospectively in terms of cause, site of perforation, surgical treatment, complications, and mortality. Only those patients who underwent exploratory laparotomy for management of perforation peritonitis were included. Results. The commonest cause of perforation peritonitis included 179 cases of peptic ulcer disease (150 duodenal ulcers and 29 gastric ulcers) followed by appendicitis (74 cases), typhoid fever (48 cases), tuberculosis (40 cases), and trauma (31). The overall mortality was 7%. Conclusions. Perforation peritonitis in India has a different spectrum as compared to the western countries. Peptic ulcer perforation, perforating appendicitis, typhoid, and tubercular perforations are the major causes of gastrointestinal perforations. Early surgical intervention under the cover of broad spectrum antibiotics preceded by adequate aggressive resuscitation and correction of electrolyte imbalances is imperative for good outcomes minimizing morbidity and mortality.

1. Introduction

Gastrointestinal perforations constitute one of the commonest surgical emergency encountered by surgeons [1, 2]. Management of these patients continues to be highly demanding despite the advances made in diagnosis and surgical therapy. The etiological spectrum of perforation peritonitis in India differs significantly from its western counter parts [35]. Our study was carried out to highlight the spectrum of perforation peritonitis (diffuse) in a single unit at Lok Nayak Hospital, a tertiary care hospital in Delhi.

2. Patients and Methods

The retrospective study was conducted at the Department of Surgery, Maulana Azad Medical College and associated Lok Nayak Hospital, Delhi, from May 2010 to June 2013. The study population included 400 patients of perforation peritonitis (diffuse or localized) presenting to the surgical emergency of Lok Nayak Hospital, Delhi, who underwent exploratory laparotomy.

Cases were studied with respect to clinical features at the time of presentation, comorbid conditions, radiological investigations, operative findings, and postoperative course. After establishing the clinical diagnosis of perforation peritonitis the patients were prepared for exploratory laparotomy. On performing exploratory laparotomy, the operative findings were noted and the source of peritonitis was found and managed accordingly. All patients were then treated in the postoperative ward initially under the cover of parenteral broad spectrum antibiotics and fluids; orals were started on the appearance of bowel sounds.

3. Results

A total of 400 patients were studied. Mean age was 37.8 years (range from 13 to 88 years). Majority of patients were males (68.5%). Male: female ratio was 2.1 : 1, respectively. 98% patients presented with the history of abdominal pain, 62.5% with altered bowel habit, 41.5% with nausea and vomiting, and 28% with abdominal distention. 15% patients had positive history of NSAID intake for more than 6 months (Table 1).


SexMale274 [68.5%]
Female126 [31.5%]

Comorbid conditionsRespiratory disease60
Diabetes mellitus41
Renal disease36

Symptoms and signsAbdominal pain392 [98%]
Altered bowel habit250 [62.5%]
Nausea and vomiting166 [41.5%]
Abdominal distention112 [28%]
Positive H/O NSAID (>6 months)61 [15.25%]
(pulse > 100/minute)
122 [30.5%]

In our study, 15% cases had associated comorbid conditions. The commonly associated comorbidity was chronic obstructive pulmonary disease followed by renal disease, diabetes, and hypertension.

79% patients had pneumoperitoneum on chest X-ray in erect posture. Multiple air fluid levels on abdominal X-ray in erect position were present in 28% patients. Electrolyte imbalances included hyponatremia in 21%, hypokalemia in 19% and elevated serum creatinine in 18% patients. Most of the patients were operated within 24 hours of presentation under the cover of broad spectrum antibiotics after adequate resuscitation and correction of electrolyte imbalances.

The commonest cause of perforation peritonitis in our study was gastroduodenal perforation due to acid peptic disease (45%) followed by appendicitis (18.5%), typhoid fever (12%), tuberculosis (10%), and trauma (9%), (Table 2).


Causes of perforation Acid peptic disease179 [44.75%]
Appendicitis74 [18.5%]
Typhoid48 [12%]
Tuberculosis40 [10%]
Trauma31 [7.75%]
Malignancy13 [3.25%]
Bowel strangulation8 [2%]
Band obstruction perforation4 [1%]
Amoebic caecal perforation3 [0.75%]

Site of perforation Duodenum150 [37.5%]
Ileum90 [22.5%]
Appendix74 [18/5%]
Jejunum38 [9.5%]
Stomach29 [7.25%]
Sigmoid colon8 [2%]
Caecum5 [1.25%]
Transverse colon3 [0.75%]
Descending colon3 [0.75%]

Surgical procedureOmental patch 175 [43.75%]
(With feeding jejunostomy)(4)
Stoma90 [22.5%]
Appendectomy68 [17%]
Primary repair27 [6.75%]
Resection-anastomosis25 [6.25%]
Limited resection with Ileo-ascending anastomosis6 [1.5%]
Right hemicolectomy5 [1.25%]

Patients of peptic ulcer perforation usually had a short history of pain starting in epigastrium followed by generalized tenderness. 34% of these patients had history of NSAID intake for 6 months. 175 such were managed by an omental pedicle repair, in the other 4 cases a feeding jejunostomy was also done due to the large size of the perforation.

Patients with appendicular perforation presented with right iliac fossa pain along with localized peritonitis. 8% of these patients were managed by a limited resection with Ileo-ascending anastomosis due to associated unhealthy caecum.

Patients of typhoid perforation had an initial history of high grade fever prior to abdominal complaints. 83% were located in the ileum and 40% were multiple.

Of the 40 patients of tubercular perforation, 60% had previous history of tuberculosis and 50% of these patients took antitubercular therapy for 6 months.

In cases of traumatic perforation, the most common site was jejunum (49%) followed by ileum (42%).

The most commonly performed procedure was omental pedicle closure of peptic ulcer perforation (43.75%), followed by exteriorization of the gut in the form of ileostomy or colostomy (22.5%). Appendectomy was the third most common procedure (17%), (Table 2).

189 out of 400 cases developed postoperative complications (Table 3).


Wound infection 125 [31.25%]
Dyselectrolytaemia 87 [21.75%]
Abdominal collection 80 [20%]
Respiratory complication 67 [16.75%]
Burst abdomen 55 [13.75%]
Anastomotic leak 6 [1.5%]
Mortality 28 [7%]

The most common complication was wound infection followed by dyselectrolytaemia, abdominal collection, and respiratory complications. The morbidity rate was higher in the patients with intestinal perforation (58%) than those with gastroduodenal perforation (32%).

The overall mortality rate was 7%. Factors involved in death included septicemia due to fecal peritonitis, respiratory complications, pulmonary embolism, and late presentation.

4. Discussion

One of the most common surgical emergencies is perforation peritonitis [6]. It is commonly seen in a younger age group in the tropical countries (mean age in our study was 37.8 years) as compared to the studies in the West [79].

More commonly the perforations involve the proximal part of the gastrointestinal tract; [1013] this being in contrast to studies from the western countries, where perforations are common in the distal part [1416].

Etiological factors also show a wide geographical variation. According to a study from India, infections formed the most common cause of perforation peritonitis [17], around 50% cases in this study were due to typhoid. In our study 22% of the cases were due to typhoid and tuberculosis. In contrast to this, Noon et al. [18] from Texas in their study reported only 2.7% cases due to infections. Also studies from the west have shown that around 15–20% cases are due to malignancy [19, 20], this being in stark contrast to our study where malignancy was ascertained to be the cause of perforation peritonitis in only 3% of the cases. This shows that malignancy is not a common cause of perforation peritonitis in our setup as compared to our western counterparts.

The overall mortality due to perforation peritonitis ranges between 6 and 27% [21]. The mortality rate in our study was 7%. One of the most important factors responsible for mortality is septicemia. Adequate preoperative resuscitation (with fluids, etc.), correction of electrolyte imbalances followed by an early surgical intervention, to remove the source of infection and stop further contamination, is imperative for good outcomes minimizing morbidity and mortality.

5. Conclusion

Perforation peritonitis in India has a different spectrum as compared to the western countries. Peptic ulcer perforation, perforating appendicitis, typhoid, and tubercular perforations are the major causes of gastrointestinal perforations. Early surgical intervention under the cover of broad spectrum antibiotics preceded by adequate aggressive resuscitation and correction of electrolyte imbalances is imperative for good outcomes minimizing morbidity and mortality.

Conflict of Interests

All the authors declare that there is no potential conflict of interests or any financial relation with the commercial identities mentioned in the paper.


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Copyright © 2014 Rajandeep Singh Bali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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